Matches in SemOpenAlex for { <https://semopenalex.org/work/W2071085763> ?p ?o ?g. }
- W2071085763 endingPage "153" @default.
- W2071085763 startingPage "148" @default.
- W2071085763 abstract "To explore the potential of a novel animal interferon formulation for controlled release, the yak interferon-alpha (IFN-α) glutathione S-transferase (GST) fusion protein was expressed in Escherichia coli (E. coli) and the purified recombinant IFN-α was encapsulated into solid lipid nanoparticles (SLN) by double emulsion solvent evaporation (w/o/w) method. The particle size and zeta potential of IFN-α-loaded SLN were 124.2 ± 10.2 nm and −11.2 ± 0.6 mV. The encapsulation efficiency of IFN-α and loading capacity of the SLN were 83.7 ± 4.5% and 1.73 ± 0.15%, respectively. In vitro release study and antiviral assay demonstrated that the IFN-α released from the SLN in a 16-day period exhibited antiviral activity in Madin–Darby bovine kidney (MDBK) cells against vesicular stomatitis virus (VSV), and showed a release pattern of an initial burst release followed by a sustained and slow release. Cytotoxicity assay in cell culture demonstrated that the SLN were not toxic. The results of this exploratory study suggest that the IFN-α-loaded SLN could be a useful formulation for controlled release in veterinary therapeutics." @default.
- W2071085763 created "2016-06-24" @default.
- W2071085763 creator A5000323275 @default.
- W2071085763 creator A5001864411 @default.
- W2071085763 creator A5010194590 @default.
- W2071085763 creator A5015264393 @default.
- W2071085763 creator A5029557705 @default.
- W2071085763 creator A5031804058 @default.
- W2071085763 creator A5033987340 @default.
- W2071085763 creator A5037595650 @default.
- W2071085763 creator A5071389166 @default.
- W2071085763 date "2010-02-01" @default.
- W2071085763 modified "2023-10-14" @default.
- W2071085763 title "Yak interferon-alpha loaded solid lipid nanoparticles for controlled release" @default.
- W2071085763 cites W1006708378 @default.
- W2071085763 cites W1579046626 @default.
- W2071085763 cites W1965052111 @default.
- W2071085763 cites W1967131786 @default.
- W2071085763 cites W1973469430 @default.
- W2071085763 cites W1974166640 @default.
- W2071085763 cites W1980221984 @default.
- W2071085763 cites W1980235567 @default.
- W2071085763 cites W1989942650 @default.
- W2071085763 cites W1991174168 @default.
- W2071085763 cites W1999507447 @default.
- W2071085763 cites W2004397732 @default.
- W2071085763 cites W2014144492 @default.
- W2071085763 cites W2022241614 @default.
- W2071085763 cites W2039623623 @default.
- W2071085763 cites W2043789726 @default.
- W2071085763 cites W2043894892 @default.
- W2071085763 cites W2045157971 @default.
- W2071085763 cites W2045633914 @default.
- W2071085763 cites W2054189154 @default.
- W2071085763 cites W2060840067 @default.
- W2071085763 cites W2064156059 @default.
- W2071085763 cites W2065254628 @default.
- W2071085763 cites W2069947692 @default.
- W2071085763 cites W2086319321 @default.
- W2071085763 cites W2086550332 @default.
- W2071085763 cites W2088534886 @default.
- W2071085763 cites W2089479233 @default.
- W2071085763 cites W2142337801 @default.
- W2071085763 cites W2144078346 @default.
- W2071085763 cites W2144580269 @default.
- W2071085763 cites W2341829866 @default.
- W2071085763 cites W3007628768 @default.
- W2071085763 cites W4248573730 @default.
- W2071085763 cites W2137281923 @default.
- W2071085763 doi "https://doi.org/10.1016/j.rvsc.2009.06.010" @default.
- W2071085763 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19647842" @default.
- W2071085763 hasPublicationYear "2010" @default.
- W2071085763 type Work @default.
- W2071085763 sameAs 2071085763 @default.
- W2071085763 citedByCount "21" @default.
- W2071085763 countsByYear W20710857632012 @default.
- W2071085763 countsByYear W20710857632013 @default.
- W2071085763 countsByYear W20710857632014 @default.
- W2071085763 countsByYear W20710857632015 @default.
- W2071085763 countsByYear W20710857632016 @default.
- W2071085763 countsByYear W20710857632017 @default.
- W2071085763 countsByYear W20710857632020 @default.
- W2071085763 countsByYear W20710857632021 @default.
- W2071085763 countsByYear W20710857632022 @default.
- W2071085763 countsByYear W20710857632023 @default.
- W2071085763 crossrefType "journal-article" @default.
- W2071085763 hasAuthorship W2071085763A5000323275 @default.
- W2071085763 hasAuthorship W2071085763A5001864411 @default.
- W2071085763 hasAuthorship W2071085763A5010194590 @default.
- W2071085763 hasAuthorship W2071085763A5015264393 @default.
- W2071085763 hasAuthorship W2071085763A5029557705 @default.
- W2071085763 hasAuthorship W2071085763A5031804058 @default.
- W2071085763 hasAuthorship W2071085763A5033987340 @default.
- W2071085763 hasAuthorship W2071085763A5037595650 @default.
- W2071085763 hasAuthorship W2071085763A5071389166 @default.
- W2071085763 hasConcept C104317684 @default.
- W2071085763 hasConcept C147789679 @default.
- W2071085763 hasConcept C153911025 @default.
- W2071085763 hasConcept C155672457 @default.
- W2071085763 hasConcept C159047783 @default.
- W2071085763 hasConcept C171250308 @default.
- W2071085763 hasConcept C185592680 @default.
- W2071085763 hasConcept C187530423 @default.
- W2071085763 hasConcept C192562407 @default.
- W2071085763 hasConcept C199529486 @default.
- W2071085763 hasConcept C2522874641 @default.
- W2071085763 hasConcept C2776178377 @default.
- W2071085763 hasConcept C2779057330 @default.
- W2071085763 hasConcept C2909179924 @default.
- W2071085763 hasConcept C40767141 @default.
- W2071085763 hasConcept C43617362 @default.
- W2071085763 hasConcept C547475151 @default.
- W2071085763 hasConcept C55493867 @default.
- W2071085763 hasConcept C86181022 @default.
- W2071085763 hasConcept C86803240 @default.
- W2071085763 hasConceptScore W2071085763C104317684 @default.
- W2071085763 hasConceptScore W2071085763C147789679 @default.
- W2071085763 hasConceptScore W2071085763C153911025 @default.