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- W2071093040 abstract "!The first clinical trial of oral methoxsalen as a potential prophylactic against skin cancer in susceptible humans was started in El Paso, Texas, in June 1957, and is reported in this same issue (1). It had been brought out in epidemiological surveys based on a functioning cancer registry in this area that skin cancers are more prevalent on exposed areas of the head, neck and hands among light skinned people in high, dry and sunny climates than elsewhere (2). Experimental studies had established that psoralen may afford some secondary protection of the skin against solar injury (3, 4, 5). An unusual opportunity for early resolution of the psoralen prophylaxis question arose when Dr. John C. Belisario of Sydney, Australia, volunteered to conduct a replicate of the El Paso trial in his large population of skin cancer patients, who are as numerous in Sydney as in El Paso. An identical protocol was drawn up providing for admission into the study of susceptible patients with a history of at least 1 documented skin cancer. Those selected had to be willing to take an experimental drug and be followed systematically at 3 months intervals for up to 3 years. After entry into the study the patients were given medication in individually numbered plain bottles which had been coded, numbered and labelled at the statistical control center. The medication was 20 mg of oral, enteric coated 8-methoxypsoralen (methoxsalen) or an identical appearing inert pill, randomly allocated by the statistical unit. A sequential trial design (6) was used as a rule for stopping the trial at the earliest time that it should become possible to detect either slightly harmful or moderately beneficial effects of the drug as compared with the inert control." @default.
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- W2071093040 date "1963-10-01" @default.
- W2071093040 modified "2023-09-28" @default.
- W2071093040 title "Psoralen Prophylaxis Against Skin Cancer: Report of Clinical Trial II" @default.
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- W2071093040 doi "https://doi.org/10.1038/jid.1963.99" @default.
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