FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2071098032> ?p ?o ?g. }

• W2071098032 endingPage "1382" @default.
• W2071098032 startingPage "1377" @default.
• W2071098032 abstract "The allergen-induced late asthmatic reaction (LAR) is associated with increases in bronchial eosinophils and basophils as well as upregulation of several eosinophil active cytokines and C-C chemokines. Cyclosporin A (CsA) was previously shown to inhibit the LAR, but not the early asthmatic reaction (EAR), and this was associated with a decrease in blood eosinophils. For these reasons, we determined whether CsA inhibited the allergen-induced increases in bronchial eosinophils, basophils, eotaxin, interleukin-5 (IL-5), and granulocyte macrophage colony-stimulating factor (GM-CSF). Subjects with a demonstrable LAR underwent bronchoscopy with biopsy and bronchoalveolar lavage (BAL) at baseline and then were randomly allocated to receive either CsA (n = 13) or placebo (n = 11) before challenge. A second bronchoscopy was performed 24 h later. The LAR, but not the EAR, was significantly attenuated in the CsA group compared with placebo (p < 0.05). CsA significantly inhibited the allergen-induced increases in IL-5 (p = 0.02) and GM-CSF (p = 0. 0028) in mRNA+ cells in BAL, and in a mAB against human activated eosinophils (EG2+) (p = 0.0227). We conclude that inhibition of the LAR by CsA may be related to its inhibitory effects on eosinophil-associated cytokines and chemokines. The beneficial effect of CsA in asthma may also be the result of inhibition of eosinophil accumulation." @default.
• W2071098032 created "2016-06-24" @default.
• W2071098032 creator A5003397190 @default.
• W2071098032 creator A5008203993 @default.
• W2071098032 creator A5018632217 @default.
• W2071098032 creator A5022388448 @default.
• W2071098032 creator A5023307885 @default.
• W2071098032 creator A5041626582 @default.
• W2071098032 creator A5043703051 @default.
• W2071098032 date "2000-10-01" @default.
• W2071098032 modified "2023-09-26" @default.
• W2071098032 title "Attenuation of the Allergen-induced Late Asthmatic Reaction by Cyclosporin A Is Associated with Inhibition of Bronchial Eosinophils, Interleukin-5, Granulocyte Macrophage Colony-Stimulating Factor, and Eotaxin" @default.
• W2071098032 cites W1583066631 @default.
• W2071098032 cites W1981370277 @default.
• W2071098032 cites W1983446181 @default.
• W2071098032 cites W1984992097 @default.
• W2071098032 cites W1985083825 @default.
• W2071098032 cites W1988939115 @default.
• W2071098032 cites W1991721349 @default.
• W2071098032 cites W1992923093 @default.
• W2071098032 cites W1993588648 @default.
• W2071098032 cites W1994362051 @default.
• W2071098032 cites W1996828073 @default.
• W2071098032 cites W2008431257 @default.
• W2071098032 cites W2023520187 @default.
• W2071098032 cites W2040031020 @default.
• W2071098032 cites W2046101189 @default.
• W2071098032 cites W2047163318 @default.
• W2071098032 cites W2048988599 @default.
• W2071098032 cites W2058323913 @default.
• W2071098032 cites W2081595143 @default.
• W2071098032 cites W2084399363 @default.
• W2071098032 cites W2095784197 @default.
• W2071098032 cites W2137907336 @default.
• W2071098032 cites W2165312997 @default.
• W2071098032 cites W2170148763 @default.
• W2071098032 doi "https://doi.org/10.1164/ajrccm.162.4.9911117" @default.
• W2071098032 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11029348" @default.
• W2071098032 hasPublicationYear "2000" @default.
• W2071098032 type Work @default.
• W2071098032 sameAs 2071098032 @default.
• W2071098032 citedByCount "67" @default.
• W2071098032 countsByYear W20710980322012 @default.
• W2071098032 countsByYear W20710980322013 @default.
• W2071098032 countsByYear W20710980322015 @default.
• W2071098032 countsByYear W20710980322017 @default.
• W2071098032 countsByYear W20710980322018 @default.
• W2071098032 crossrefType "journal-article" @default.
• W2071098032 hasAuthorship W2071098032A5003397190 @default.
• W2071098032 hasAuthorship W2071098032A5008203993 @default.
• W2071098032 hasAuthorship W2071098032A5018632217 @default.
• W2071098032 hasAuthorship W2071098032A5022388448 @default.
• W2071098032 hasAuthorship W2071098032A5023307885 @default.
• W2071098032 hasAuthorship W2071098032A5041626582 @default.
• W2071098032 hasAuthorship W2071098032A5043703051 @default.
• W2071098032 hasConcept C126322002 @default.
• W2071098032 hasConcept C13373296 @default.
• W2071098032 hasConcept C181901479 @default.
• W2071098032 hasConcept C203014093 @default.
• W2071098032 hasConcept C207480886 @default.
• W2071098032 hasConcept C2776042228 @default.
• W2071098032 hasConcept C2776914184 @default.
• W2071098032 hasConcept C2777037409 @default.
• W2071098032 hasConcept C2777478134 @default.
• W2071098032 hasConcept C2777714996 @default.
• W2071098032 hasConcept C2777716647 @default.
• W2071098032 hasConcept C2777961210 @default.
• W2071098032 hasConcept C2777983669 @default.
• W2071098032 hasConcept C2778081958 @default.
• W2071098032 hasConcept C2778690821 @default.
• W2071098032 hasConcept C2780510475 @default.
• W2071098032 hasConcept C71924100 @default.
• W2071098032 hasConcept C74172505 @default.
• W2071098032 hasConceptScore W2071098032C126322002 @default.
• W2071098032 hasConceptScore W2071098032C13373296 @default.
• W2071098032 hasConceptScore W2071098032C181901479 @default.
• W2071098032 hasConceptScore W2071098032C203014093 @default.
• W2071098032 hasConceptScore W2071098032C207480886 @default.
• W2071098032 hasConceptScore W2071098032C2776042228 @default.
• W2071098032 hasConceptScore W2071098032C2776914184 @default.
• W2071098032 hasConceptScore W2071098032C2777037409 @default.
• W2071098032 hasConceptScore W2071098032C2777478134 @default.
• W2071098032 hasConceptScore W2071098032C2777714996 @default.
• W2071098032 hasConceptScore W2071098032C2777716647 @default.
• W2071098032 hasConceptScore W2071098032C2777961210 @default.
• W2071098032 hasConceptScore W2071098032C2777983669 @default.
• W2071098032 hasConceptScore W2071098032C2778081958 @default.
• W2071098032 hasConceptScore W2071098032C2778690821 @default.
• W2071098032 hasConceptScore W2071098032C2780510475 @default.
• W2071098032 hasConceptScore W2071098032C71924100 @default.
• W2071098032 hasConceptScore W2071098032C74172505 @default.
• W2071098032 hasIssue "4" @default.
• W2071098032 hasLocation W20710980321 @default.
• W2071098032 hasLocation W20710980322 @default.
• W2071098032 hasOpenAccess W2071098032 @default.
• W2071098032 hasPrimaryLocation W20710980321 @default.
• W2071098032 hasRelatedWork W1691245493 @default.
• W2071098032 hasRelatedWork W1833894873 @default.

• next