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- W2071110001 abstract "The early conceptus (embryo and associated membranes) of domestic ruminants signals its presence to the maternal uterus through production of interferon-τ (IFN-τ). Production of IFN-τ ensures continued production of progesterone, the hormone of pregnancy, by the ovarian corpus luteum. This paper reports the high-level expression and efficient secretion of biologically active recombinant ovine IFN-τ (rOvIFN-τ) by Pichia pastoris. The developed method produces more than 80% pure recombinant ovine IFN-τ, obviating the need for further purification for many purposes. Initial fermentation studies produced IFN-τ at 280 mg/liter and demonstrate the potential of this system for large-scale production of IFN-τ." @default.
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- W2071110001 date "1996-02-01" @default.
- W2071110001 modified "2023-09-27" @default.
- W2071110001 title "High Yield Expression and Secretion of the Ovine Pregnancy Recognition Hormone Interferon-τ by<i>Pichia pastoris</i>" @default.
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- W2071110001 doi "https://doi.org/10.1089/jir.1996.16.119" @default.
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