FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2071117135> ?p ?o ?g. }

• W2071117135 endingPage "180" @default.
• W2071117135 startingPage "175" @default.
• W2071117135 abstract "This study reports on the interactive effects of ethanol and caffeine on growth of rat fetal hepatocytes. Exposure of cultured rat fetal hepatocytes (RFH) to ethanol in concentrations above 1 mg/ml, causes a blockade of EGF-dependent cell replication along with an overexpression of surface EGF receptors (EGF-R). However, RFHs exposed for 24 hours to ethanol at a concentration of 1 mg/ml alone had little effect on cell replication. Caffeine, when combined with this concentration of alcohol, progressively impaired RFH growth by up to 100%. Caffeine alone up to 10 micrograms/ml, on the other hand, caused a progressive increase in RFH replication associated with a 69% enhancement of DNA synthesis. Caffeine concentrations in excess of 50 micrograms/ml had no effect on replicative capacity. Concomitant caffeine exposure had no effect on the ethanol-related increase in cell DNA content, yet it caused a further enhancement of the cell protein accural induced by ethanol alone. Caffeine (10 micrograms/ml) alone had no effect on EGF-R expression, while ethanol (2 mg/ml) increased it by almost 200%. Addition of caffeine to ethanol reduced this enhanced EGF binding by 45%. Scatchard analysis indicated that no treatment altered ligand affinity for the receptor, but that the alterations in binding caused by ethanol and the caffeine/ethanol combination reflected changes in binding capacity, in both low and high affinity components. It is concluded that (1) ethanol blocks EGF-mediated replication accompanied by a reduction in DNA synthesis, (2) caffeine alone at low concentrations has the opposite effect and can actually potentiate the EGF-mediated mitogenic response, (3) caffeine in combination with ethanol acts synergistically to reduce RFH replication.(ABSTRACT TRUNCATED AT 250 WORDS)" @default.
• W2071117135 created "2016-06-24" @default.
• W2071117135 creator A5020762705 @default.
• W2071117135 creator A5068949374 @default.
• W2071117135 creator A5071988751 @default.
• W2071117135 creator A5090234645 @default.
• W2071117135 date "1991-04-01" @default.
• W2071117135 modified "2023-09-23" @default.
• W2071117135 title "Interactive Effects of Ethanol and Caffeine on Rat Fetal Hepatocyte Replication and EGF Receptor Expression" @default.
• W2071117135 cites W1532303198 @default.
• W2071117135 cites W1966170623 @default.
• W2071117135 cites W1967025529 @default.
• W2071117135 cites W1970693682 @default.
• W2071117135 cites W1971531701 @default.
• W2071117135 cites W1972811633 @default.
• W2071117135 cites W2001578819 @default.
• W2071117135 cites W2013672165 @default.
• W2071117135 cites W2014034994 @default.
• W2071117135 cites W2022879761 @default.
• W2071117135 cites W2033457242 @default.
• W2071117135 cites W2041090971 @default.
• W2071117135 cites W2047178138 @default.
• W2071117135 cites W2052050297 @default.
• W2071117135 cites W2063968999 @default.
• W2071117135 cites W207524507 @default.
• W2071117135 cites W2077257463 @default.
• W2071117135 cites W2080894880 @default.
• W2071117135 cites W2086313404 @default.
• W2071117135 cites W2088188556 @default.
• W2071117135 cites W2091101569 @default.
• W2071117135 cites W2091111721 @default.
• W2071117135 cites W2104788447 @default.
• W2071117135 cites W2146123028 @default.
• W2071117135 cites W2149159297 @default.
• W2071117135 cites W2280752505 @default.
• W2071117135 cites W2411564279 @default.
• W2071117135 cites W2497620683 @default.
• W2071117135 cites W25670294 @default.
• W2071117135 cites W4300999124 @default.
• W2071117135 doi "https://doi.org/10.1111/j.1530-0277.1991.tb01850.x" @default.
• W2071117135 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2058791" @default.
• W2071117135 hasPublicationYear "1991" @default.
• W2071117135 type Work @default.
• W2071117135 sameAs 2071117135 @default.
• W2071117135 citedByCount "11" @default.
• W2071117135 crossrefType "journal-article" @default.
• W2071117135 hasAuthorship W2071117135A5020762705 @default.
• W2071117135 hasAuthorship W2071117135A5068949374 @default.
• W2071117135 hasAuthorship W2071117135A5071988751 @default.
• W2071117135 hasAuthorship W2071117135A5090234645 @default.
• W2071117135 hasConcept C126322002 @default.
• W2071117135 hasConcept C134018914 @default.
• W2071117135 hasConcept C170493617 @default.
• W2071117135 hasConcept C185592680 @default.
• W2071117135 hasConcept C202751555 @default.
• W2071117135 hasConcept C2776200302 @default.
• W2071117135 hasConcept C2776362946 @default.
• W2071117135 hasConcept C2778500429 @default.
• W2071117135 hasConcept C2780161600 @default.
• W2071117135 hasConcept C2781066024 @default.
• W2071117135 hasConcept C54355233 @default.
• W2071117135 hasConcept C55493867 @default.
• W2071117135 hasConcept C62112901 @default.
• W2071117135 hasConcept C71924100 @default.
• W2071117135 hasConcept C81885089 @default.
• W2071117135 hasConcept C86803240 @default.
• W2071117135 hasConceptScore W2071117135C126322002 @default.
• W2071117135 hasConceptScore W2071117135C134018914 @default.
• W2071117135 hasConceptScore W2071117135C170493617 @default.
• W2071117135 hasConceptScore W2071117135C185592680 @default.
• W2071117135 hasConceptScore W2071117135C202751555 @default.
• W2071117135 hasConceptScore W2071117135C2776200302 @default.
• W2071117135 hasConceptScore W2071117135C2776362946 @default.
• W2071117135 hasConceptScore W2071117135C2778500429 @default.
• W2071117135 hasConceptScore W2071117135C2780161600 @default.
• W2071117135 hasConceptScore W2071117135C2781066024 @default.
• W2071117135 hasConceptScore W2071117135C54355233 @default.
• W2071117135 hasConceptScore W2071117135C55493867 @default.
• W2071117135 hasConceptScore W2071117135C62112901 @default.
• W2071117135 hasConceptScore W2071117135C71924100 @default.
• W2071117135 hasConceptScore W2071117135C81885089 @default.
• W2071117135 hasConceptScore W2071117135C86803240 @default.
• W2071117135 hasIssue "2" @default.
• W2071117135 hasLocation W20711171351 @default.
• W2071117135 hasLocation W20711171352 @default.
• W2071117135 hasOpenAccess W2071117135 @default.
• W2071117135 hasPrimaryLocation W20711171351 @default.
• W2071117135 hasRelatedWork W1994789631 @default.
• W2071117135 hasRelatedWork W2007465681 @default.
• W2071117135 hasRelatedWork W2018368842 @default.
• W2071117135 hasRelatedWork W2021560856 @default.
• W2071117135 hasRelatedWork W2032639135 @default.
• W2071117135 hasRelatedWork W2034583712 @default.
• W2071117135 hasRelatedWork W2037767894 @default.
• W2071117135 hasRelatedWork W2044826694 @default.
• W2071117135 hasRelatedWork W2063619316 @default.
• W2071117135 hasRelatedWork W2071117135 @default.
• W2071117135 hasVolume "15" @default.

• next