Matches in SemOpenAlex for { <https://semopenalex.org/work/W2071120706> ?p ?o ?g. }
- W2071120706 endingPage "30" @default.
- W2071120706 startingPage "23" @default.
- W2071120706 abstract "The ligand-dependent activation of the JAK/STAT (Januskinase/Signal Transducer and Activator of Transcription) pathway has been implicated in the explanation of cytokine-specific regulation of gene expression. Previous studies have reported conflicting results on the role of the transcription factor STAT5 in erythropoietin (EPO)-induced cellular responses. In this study we focused on the functional importance of STAT5 docking sites in the intracellular EPO receptor (EPOR) domain for the mediation of antiapoptotic activities. We demonstrate that EPO-dependent survival of erythroleukemic cell lines is accompanied by sustained STAT5 DNA-binding activity. The role of single tyrosine residues was dissected by the analysis of myeloid FDCP-1 cells stably expressing mutant EPOR proteins. The data show that receptors having a high potential to mediate antiapoptotic signals also effectively activate STAT5, whereas receptors lacking STAT5 docking sites are diminished in both activities. We conclude that the transcription factor STAT5 is functionally implicated in the EPO-dependent survival of cells." @default.
- W2071120706 created "2016-06-24" @default.
- W2071120706 creator A5003788067 @default.
- W2071120706 creator A5019793360 @default.
- W2071120706 creator A5022264195 @default.
- W2071120706 creator A5056922048 @default.
- W2071120706 creator A5061004891 @default.
- W2071120706 creator A5061084695 @default.
- W2071120706 date "2000-01-01" @default.
- W2071120706 modified "2023-09-27" @default.
- W2071120706 title "Activation of STAT5 during EPO-directed suppression of apoptosis" @default.
- W2071120706 cites W146679683 @default.
- W2071120706 cites W1538909114 @default.
- W2071120706 cites W1578727637 @default.
- W2071120706 cites W1603378909 @default.
- W2071120706 cites W1606072873 @default.
- W2071120706 cites W1900781903 @default.
- W2071120706 cites W1964049279 @default.
- W2071120706 cites W1964815717 @default.
- W2071120706 cites W1979898548 @default.
- W2071120706 cites W1983823652 @default.
- W2071120706 cites W1984866351 @default.
- W2071120706 cites W2006192370 @default.
- W2071120706 cites W2011030679 @default.
- W2071120706 cites W2012628280 @default.
- W2071120706 cites W2013036001 @default.
- W2071120706 cites W2014453564 @default.
- W2071120706 cites W2019663245 @default.
- W2071120706 cites W2020337983 @default.
- W2071120706 cites W2029860358 @default.
- W2071120706 cites W2045427520 @default.
- W2071120706 cites W2050706918 @default.
- W2071120706 cites W2050985097 @default.
- W2071120706 cites W2058706806 @default.
- W2071120706 cites W2067626539 @default.
- W2071120706 cites W2070273393 @default.
- W2071120706 cites W2090305802 @default.
- W2071120706 cites W2094646101 @default.
- W2071120706 cites W2095861062 @default.
- W2071120706 cites W2100869656 @default.
- W2071120706 cites W2103807332 @default.
- W2071120706 cites W2122601432 @default.
- W2071120706 cites W2137048049 @default.
- W2071120706 cites W2147028876 @default.
- W2071120706 cites W2316484365 @default.
- W2071120706 cites W2394340684 @default.
- W2071120706 cites W2408546921 @default.
- W2071120706 cites W2411943916 @default.
- W2071120706 cites W334134150 @default.
- W2071120706 cites W77986286 @default.
- W2071120706 cites W87041013 @default.
- W2071120706 doi "https://doi.org/10.1016/s0898-6568(99)00063-7" @default.
- W2071120706 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10676844" @default.
- W2071120706 hasPublicationYear "2000" @default.
- W2071120706 type Work @default.
- W2071120706 sameAs 2071120706 @default.
- W2071120706 citedByCount "34" @default.
- W2071120706 countsByYear W20711207062013 @default.
- W2071120706 countsByYear W20711207062015 @default.
- W2071120706 countsByYear W20711207062016 @default.
- W2071120706 countsByYear W20711207062017 @default.
- W2071120706 countsByYear W20711207062019 @default.
- W2071120706 countsByYear W20711207062021 @default.
- W2071120706 countsByYear W20711207062023 @default.
- W2071120706 crossrefType "journal-article" @default.
- W2071120706 hasAuthorship W2071120706A5003788067 @default.
- W2071120706 hasAuthorship W2071120706A5019793360 @default.
- W2071120706 hasAuthorship W2071120706A5022264195 @default.
- W2071120706 hasAuthorship W2071120706A5056922048 @default.
- W2071120706 hasAuthorship W2071120706A5061004891 @default.
- W2071120706 hasAuthorship W2071120706A5061084695 @default.
- W2071120706 hasConcept C104317684 @default.
- W2071120706 hasConcept C134018914 @default.
- W2071120706 hasConcept C171958077 @default.
- W2071120706 hasConcept C2778277574 @default.
- W2071120706 hasConcept C2778534260 @default.
- W2071120706 hasConcept C2778923194 @default.
- W2071120706 hasConcept C2779391668 @default.
- W2071120706 hasConcept C31102739 @default.
- W2071120706 hasConcept C32465701 @default.
- W2071120706 hasConcept C502942594 @default.
- W2071120706 hasConcept C55493867 @default.
- W2071120706 hasConcept C62478195 @default.
- W2071120706 hasConcept C65439459 @default.
- W2071120706 hasConcept C86339819 @default.
- W2071120706 hasConcept C86803240 @default.
- W2071120706 hasConcept C95444343 @default.
- W2071120706 hasConceptScore W2071120706C104317684 @default.
- W2071120706 hasConceptScore W2071120706C134018914 @default.
- W2071120706 hasConceptScore W2071120706C171958077 @default.
- W2071120706 hasConceptScore W2071120706C2778277574 @default.
- W2071120706 hasConceptScore W2071120706C2778534260 @default.
- W2071120706 hasConceptScore W2071120706C2778923194 @default.
- W2071120706 hasConceptScore W2071120706C2779391668 @default.
- W2071120706 hasConceptScore W2071120706C31102739 @default.
- W2071120706 hasConceptScore W2071120706C32465701 @default.
- W2071120706 hasConceptScore W2071120706C502942594 @default.
- W2071120706 hasConceptScore W2071120706C55493867 @default.