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• W2071120934 abstract "Class A-class C mechanism-based beta-lactamase inhibitors were designed on the basis of the intermediacy of an oxycarbenium species capable of cross-linking with amino acids residues in the active site. Penams 24 and 27 were very potent against AmpC in vitro. The MIC values of 24 in combination with piperacillin against class A and class C producing organisms showed improvement over clinically used tazobactam." @default.
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• W2071120934 date "2003-05-23" @default.
• W2071120934 modified "2023-10-07" @default.
• W2071120934 title "Spirocyclopropyl β-Lactams as Mechanism-Based Inhibitors of Serine β-Lactamases. Synthesis by Rhodium-Catalyzed Cyclopropanation of 6-Diazopenicillanate Sulfone" @default.
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• W2071120934 doi "https://doi.org/10.1021/jm034056q" @default.
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