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- W2071121331 abstract "Abstract Male weanling Lewis rats were fed two concentrations of copper (0.6 or 5.6 ug Cu/g diet) for 42 days. Rats consuming the low copper diet had lower hemoglobin, hematocrit, serum ceruloplasmin activity, and copper and iron concentrations than those fed the adequate copper diet. Copper-deficient (CuD) rats had elevated liver iron. Concanavalin-A (Con-A)-induced incorporation of 3 H-thymidine ( 3 H-TdR) was suppressed in erythrocyte-free suspensions of splenic lymphoid cells from CuD rats, but not in spleen cell suspensions containing resident erythrocytes. Addition of either erythrocytes or latex particles to preparations of splenic lymphoid cells that had been treated with ammonium chloride (LSLC) enhanced the mitogenic reactivity of splenic T-lymphocytes from CuD rats relative to that of the controls. LSLC from CuD rats required four times as many latex particles per cell for maximal T-lymphocyte reactivity to Con-A than did cells from copper-adequate (CuA) rats. These results suggest that copper deficiency is associated with enhanced activity or number of suppressor macrophages in the spleen. Such an alteration may contribute to the immunocompromised state found in copper-deficient rodents." @default.
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- W2071121331 date "1990-03-01" @default.
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- W2071121331 title "Erythrocytes and latex particles enhance blastogenesis of concanavalin—A stimulated spleen lymphoid cells from copper deficient rats" @default.
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- W2071121331 doi "https://doi.org/10.1016/s0271-5317(05)80272-6" @default.
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