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- W2071124329 abstract "Abstract The nature of the oncornavirus inactivating factor (OIF) contained in the normal sera of certain mouse strains was investigated by various biochemical and biological techniques. The OIF copurified quantitatively with the lipoprotein fraction of STU mouse serum subjected to flotation through sucrose density gradients. The buoyant material consisted of a heterogenous population of spherical particles (200–1200 A) which had a density 70%) lipid moiety. All of these properties are characteristic of serum very low-density lipoproteins (VLDL) and, therefore, suggest that OIF is contained in the VLDL fraction of normal mouse serum. In contrast to whole serum which specifically inactivated xenotropic and polytropic murine oncornaviruses, the isolated VLDL fraction was also able to inactivate murine ecotropic viruses and feline leukemia virus. Fractionation of STU lipoproteins or whole serum by extraction with ether:ethanol (3:1) removed the OIF into the organic solvent. This factor extract inactivated the same spectrum of viruses as serum VLDL. However, sodium dodecyl sulfate-polyacrylamide gel electrophoresis analysis of unlabeled and radioiodinated factor extracts revealed no detectable protein components. Thus, the inactivating capacity of normal serum apparently can be mediated by lipid micelles devoid of protein. NIH Swiss mouse sera, previously reported not to have OIF, did harbor high titers of factor in an inactive form which displayed activity upon flotation or after extraction with ether: ethanol. However, this phenomenon was specific for NIH mouse sera, since VLDL and ether:ethanol extracted fractions of sera from a number of mammalian species were not found to be active against xenotropic or recombinant murine leukemia viruses (MuLVs). In view of the potential role of recombinant MuLVs in murine leukemia, sera of individual AKR mice were serially examined for a diminution of OIF in the preleukemia or leukemic stages of the disease. Also, serial bleedings were tested from individual C57B1 mice prior to and after irradiation and then monthly until the development of radiation-induced leukemia. In both cases, no apparent significant reduction of OIF titer was observed." @default.
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- W2071124329 date "1979-10-01" @default.
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- W2071124329 title "Further characterization of the oncornavirus inactivating factor in normal mouse serum" @default.
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- W2071124329 doi "https://doi.org/10.1016/0042-6822(79)90521-x" @default.
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