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- W2071128923 abstract "The incidence of prostate cancer (PCa) has risen in most Western and Eastern countries during the last 15 yr. Most detected tumours have a lower grade and stage than in the past. The increasing number of biopsies, the increasing number of cores per biopsy, the increasing overall life expectancy, and most importantly, the increasing use of prostate-specific antigen (PSA) measurements as screening tests, with lower thresholds for biopsy, account for this development [1]. The majority of these screendetected tumours have favourable characteristics, with a beneficial long-term survival [2]. Many of these malignancies would most probably not have caused any symptoms during a man’s lifetime if they had remained undiagnosed. This so-called over-diagnosis due to screening often results in over-treatment, subjecting men to unnecessary costly and invasive treatment with the risk of important side-effects [3,4]. Men screened for PCa should be protected against this. The replacement of initial active treatment with active surveillance in patients with small, localised, well-differentiated PCa contributes to achieving this aim. Quality of life might also be preserved longer with this strategy. Because screening for PCa is frequently applied, the attention to this approach in this specific subgroup of men with PCa has increased. There is a rising demand for an evidence-based approach, but unfortunately it is not yet available. Uncertainties currently exist concerning the risk of missing the window of curability in PCa and criteria to rely on for changing from active surveillance to curative" @default.
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- W2071128923 date "2007-12-01" @default.
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- W2071128923 title "Prospective Validation of Active Surveillance in Prostate Cancer: The PRIAS Study" @default.
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- W2071128923 doi "https://doi.org/10.1016/j.eururo.2007.05.011" @default.
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