Matches in SemOpenAlex for { <https://semopenalex.org/work/W2071132017> ?p ?o ?g. }
- W2071132017 endingPage "15787" @default.
- W2071132017 startingPage "15782" @default.
- W2071132017 abstract "The interplay of environmental and genetic factors in the developmental organization of the hippocampus has not been fully elucidated. The neuropeptide corticotropin-releasing factor (CRF) is released from hippocampal interneurons by environmental signals, including stress, to increase synaptic efficacy. In the early postnatal hippocampus, we have previously characterized a transient population of CRF-expressing Cajal-Retzius-like cells. Here we queried whether this stress-activated neuromodulator influences connectivity in the developing hippocampal network. Using mice deficient in the principal hippocampal CRF receptor [CRF 1 (-/-)] and organotypic cultures grown in the presence of synthetic CRF, or CRF receptor antagonists, we found robust effects of CRF on dendritic differentiation in hippocampal neurons. In CRF 1 (-/-) mice, the dendritic trees of hippocampal principal cells were exuberant, an effect that was induced in normal hippocampi in vitro by the presence of CRF 1 antagonists. In both cases, total dendritic length and dendritic branching were significantly increased. In contrast, exogenous synthetic CRF blunted the dendritic growth in hippocampal organotypic cultures. Taken together, these findings suggest that endogenous CRF, if released excessively by previous early postnatal stress, might influence neuronal connectivity and thus function of the immature hippocampus." @default.
- W2071132017 created "2016-06-24" @default.
- W2071132017 creator A5013650446 @default.
- W2071132017 creator A5019593501 @default.
- W2071132017 creator A5027520924 @default.
- W2071132017 creator A5051246803 @default.
- W2071132017 creator A5051388310 @default.
- W2071132017 creator A5052614648 @default.
- W2071132017 creator A5053058372 @default.
- W2071132017 date "2004-10-20" @default.
- W2071132017 modified "2023-09-30" @default.
- W2071132017 title "Modulation of dendritic differentiation by corticotropin-releasing factor in the developing hippocampus" @default.
- W2071132017 cites W1119936408 @default.
- W2071132017 cites W1519700610 @default.
- W2071132017 cites W1527225576 @default.
- W2071132017 cites W1578782149 @default.
- W2071132017 cites W1662235811 @default.
- W2071132017 cites W1681520334 @default.
- W2071132017 cites W1821389696 @default.
- W2071132017 cites W1951492130 @default.
- W2071132017 cites W1978641918 @default.
- W2071132017 cites W1979890518 @default.
- W2071132017 cites W1982248825 @default.
- W2071132017 cites W1991262327 @default.
- W2071132017 cites W2004213733 @default.
- W2071132017 cites W2010926658 @default.
- W2071132017 cites W2010963733 @default.
- W2071132017 cites W2012416101 @default.
- W2071132017 cites W2013632767 @default.
- W2071132017 cites W2014389693 @default.
- W2071132017 cites W2020673470 @default.
- W2071132017 cites W2021645572 @default.
- W2071132017 cites W2022888964 @default.
- W2071132017 cites W2023195093 @default.
- W2071132017 cites W2024285581 @default.
- W2071132017 cites W2025299701 @default.
- W2071132017 cites W2027478213 @default.
- W2071132017 cites W2028496416 @default.
- W2071132017 cites W2029108413 @default.
- W2071132017 cites W2039736236 @default.
- W2071132017 cites W2041736210 @default.
- W2071132017 cites W2044331640 @default.
- W2071132017 cites W2045749433 @default.
- W2071132017 cites W2049521887 @default.
- W2071132017 cites W2052086914 @default.
- W2071132017 cites W2054258344 @default.
- W2071132017 cites W2061622320 @default.
- W2071132017 cites W2062050838 @default.
- W2071132017 cites W2062721613 @default.
- W2071132017 cites W2065958702 @default.
- W2071132017 cites W2070651871 @default.
- W2071132017 cites W2071635877 @default.
- W2071132017 cites W2073697680 @default.
- W2071132017 cites W2080726679 @default.
- W2071132017 cites W2081713212 @default.
- W2071132017 cites W2085287004 @default.
- W2071132017 cites W2093145540 @default.
- W2071132017 cites W2093574478 @default.
- W2071132017 cites W2094968565 @default.
- W2071132017 cites W2095036452 @default.
- W2071132017 cites W2100836659 @default.
- W2071132017 cites W2107246545 @default.
- W2071132017 cites W2112572641 @default.
- W2071132017 cites W2117794423 @default.
- W2071132017 cites W2128922109 @default.
- W2071132017 cites W2130183688 @default.
- W2071132017 cites W2130347268 @default.
- W2071132017 cites W2149594633 @default.
- W2071132017 cites W2149995749 @default.
- W2071132017 cites W2152541584 @default.
- W2071132017 cites W2153085409 @default.
- W2071132017 cites W2158275225 @default.
- W2071132017 cites W2163339962 @default.
- W2071132017 cites W2168521535 @default.
- W2071132017 cites W2169015964 @default.
- W2071132017 cites W2231571999 @default.
- W2071132017 cites W2480691165 @default.
- W2071132017 cites W29220814 @default.
- W2071132017 doi "https://doi.org/10.1073/pnas.0403975101" @default.
- W2071132017 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/524840" @default.
- W2071132017 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15496472" @default.
- W2071132017 hasPublicationYear "2004" @default.
- W2071132017 type Work @default.
- W2071132017 sameAs 2071132017 @default.
- W2071132017 citedByCount "161" @default.
- W2071132017 countsByYear W20711320172012 @default.
- W2071132017 countsByYear W20711320172013 @default.
- W2071132017 countsByYear W20711320172014 @default.
- W2071132017 countsByYear W20711320172015 @default.
- W2071132017 countsByYear W20711320172016 @default.
- W2071132017 countsByYear W20711320172017 @default.
- W2071132017 countsByYear W20711320172018 @default.
- W2071132017 countsByYear W20711320172019 @default.
- W2071132017 countsByYear W20711320172020 @default.
- W2071132017 countsByYear W20711320172021 @default.
- W2071132017 countsByYear W20711320172022 @default.
- W2071132017 countsByYear W20711320172023 @default.
- W2071132017 crossrefType "journal-article" @default.