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- W2071150820 abstract "Objectives: The aim was to examine the gene environment (GxE) interaction with reference to APO E genotypes, serum lipids and organochlorine pesticides (OCPs) as one of the factors in the etiology of Alzheimer’s disease (AD). Methods: A case control study was used to examine, APOE HhaI polymorphism by polymerase chain reaction (PCR)/PCRrestriction fragment length polymorphism method, serum lipids by autoanalyser and OCPs by gas chromatography (GC). Results: APOE ∊4 allele frequency was significantly high (p=0.000, OR=5.73, CI=2.68-12.50) in AD as compared to controls. The serum cholesterol, β- hexachlorocyclohexane and dieldrin are risk factors for AD independent of the APOE ∊4 risk allele, recording an odds ratio of 1.16, 11.38 and 10.45 respectively. Conclusion: GxE interactions exist with APOE ∊4 allele status that need to be considered for the study design and analysis of such data in future studies of AD." @default.
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- W2071150820 date "2012-08-17" @default.
- W2071150820 modified "2023-09-28" @default.
- W2071150820 title "Gene–Environment Interaction in Alzheimer’s Disease" @default.
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- W2071150820 doi "https://doi.org/10.1177/1533317512456067" @default.
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