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- W2071166752 abstract "In the present study, the morphological, histochemical, biochemical, and cellular aspects of the pathogenesis of bromodeoxyuridine (BrdU)-induced cleft palate in hamster fetuses were analyzed. Morphological observations indicated that BrdU interferes with the growth of the vertical shelves and thus induces cleft palate. At an ultrastructural level, BrdU-induced changes were first seen in the mesenchymal cells. Eighteen hours after drug administration, the initial alterations were characterized by swelling of the nuclear membrane and the appearance of lysosomes in the mesenchymal cells of the roof of the oronasal cavity. During the next 6 hr, as the palatal primordia developed, lysosomes were also seen in the overlying epithelial cells. The appearance of lysosomal activity, which was verified by acid phosphatase histochemistry, was temporally abnormal and was interpreted as a sublethal response to BrdU treatment. Later the cellular alterations subsided; 48 hr after BrdU treatment, they were absent in both the epithelial and mesenchymal cells of the vertically developing palatal shelves. Subsequently, unlike controls (in which the palatal shelves undergo reorientation and fusion), the BrdU-treated shelves remained vertical until term. Biochemical determination of DNA synthesis indicated that although there was an inhibition of DNA synthesis at the time of appearance of palatal primordia, a catch-up growth during the ensuing 12 hr may have restored the number of cells available for the formation of a vertical palatal shelf. It was suggested that BrdU affected cytodifferentiation in the palatal tissues during the critical phase of early vertical development to induce a cleft palate." @default.
- W2071166752 created "2016-06-24" @default.
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- W2071166752 creator A5040448780 @default.
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- W2071166752 date "1991-03-01" @default.
- W2071166752 modified "2023-10-13" @default.
- W2071166752 title "Pathogenesis of bromodeoxyuridine-induced cleft palate in hamster" @default.
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- W2071166752 doi "https://doi.org/10.1002/aja.1001900303" @default.
- W2071166752 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2048551" @default.
- W2071166752 hasPublicationYear "1991" @default.
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