FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2071181330> ?p ?o ?g. }

• W2071181330 endingPage "17435" @default.
• W2071181330 startingPage "17430" @default.
• W2071181330 abstract "Host-cell factor 1 (HCF-1) is an unusual transcriptional regulator that undergoes a process of proteolytic maturation to generate N- (HCF-1(N)) and C- (HCF-1(C)) terminal subunits noncovalently associated via self-association sequence elements. Here, we present the crystal structure of the self-association sequence 1 (SAS1) including the adjacent C-terminal HCF-1 nuclear localization signal (NLS). SAS1 elements from each of the HCF-1(N) and HCF-1(C) subunits form an interdigitated fibronectin type 3 (Fn3) tandem repeat structure. We show that the C-terminal NLS recruited by the interdigitated SAS1 structure is required for effective formation of a transcriptional regulatory complex: the herpes simplex virus VP16-induced complex. Thus, HCF-1(N)-HCF-1(C) association via an integrated Fn3 structure permits an NLS to facilitate formation of a transcriptional regulatory complex." @default.
• W2071181330 created "2016-06-24" @default.
• W2071181330 creator A5012934386 @default.
• W2071181330 creator A5043292394 @default.
• W2071181330 creator A5046713411 @default.
• W2071181330 creator A5059441508 @default.
• W2071181330 date "2012-10-08" @default.
• W2071181330 modified "2023-09-24" @default.
• W2071181330 title "HCF-1 self-association via an interdigitated Fn3 structure facilitates transcriptional regulatory complex formation" @default.
• W2071181330 cites W1977798848 @default.
• W2071181330 cites W1987625849 @default.
• W2071181330 cites W1994150489 @default.
• W2071181330 cites W1998983301 @default.
• W2071181330 cites W2003053220 @default.
• W2071181330 cites W2011854550 @default.
• W2071181330 cites W2031590347 @default.
• W2071181330 cites W2040328437 @default.
• W2071181330 cites W2042584499 @default.
• W2071181330 cites W2095491514 @default.
• W2071181330 cites W2109274843 @default.
• W2071181330 cites W2109361919 @default.
• W2071181330 cites W2116196682 @default.
• W2071181330 cites W2120628024 @default.
• W2071181330 cites W2125161768 @default.
• W2071181330 cites W2127015328 @default.
• W2071181330 cites W2136206805 @default.
• W2071181330 cites W2150056778 @default.
• W2071181330 cites W2162674261 @default.
• W2071181330 cites W2165864695 @default.
• W2071181330 cites W2285107724 @default.
• W2071181330 doi "https://doi.org/10.1073/pnas.1208378109" @default.
• W2071181330 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3491465" @default.
• W2071181330 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23045687" @default.
• W2071181330 hasPublicationYear "2012" @default.
• W2071181330 type Work @default.
• W2071181330 sameAs 2071181330 @default.
• W2071181330 citedByCount "11" @default.
• W2071181330 countsByYear W20711813302013 @default.
• W2071181330 countsByYear W20711813302014 @default.
• W2071181330 countsByYear W20711813302015 @default.
• W2071181330 countsByYear W20711813302016 @default.
• W2071181330 countsByYear W20711813302019 @default.
• W2071181330 crossrefType "journal-article" @default.
• W2071181330 hasAuthorship W2071181330A5012934386 @default.
• W2071181330 hasAuthorship W2071181330A5043292394 @default.
• W2071181330 hasAuthorship W2071181330A5046713411 @default.
• W2071181330 hasAuthorship W2071181330A5059441508 @default.
• W2071181330 hasBestOaLocation W20711813301 @default.
• W2071181330 hasConcept C104317684 @default.
• W2071181330 hasConcept C167625842 @default.
• W2071181330 hasConcept C185592680 @default.
• W2071181330 hasConcept C186435350 @default.
• W2071181330 hasConcept C27153228 @default.
• W2071181330 hasConcept C2778112365 @default.
• W2071181330 hasConcept C49805395 @default.
• W2071181330 hasConcept C54355233 @default.
• W2071181330 hasConcept C86339819 @default.
• W2071181330 hasConcept C86803240 @default.
• W2071181330 hasConceptScore W2071181330C104317684 @default.
• W2071181330 hasConceptScore W2071181330C167625842 @default.
• W2071181330 hasConceptScore W2071181330C185592680 @default.
• W2071181330 hasConceptScore W2071181330C186435350 @default.
• W2071181330 hasConceptScore W2071181330C27153228 @default.
• W2071181330 hasConceptScore W2071181330C2778112365 @default.
• W2071181330 hasConceptScore W2071181330C49805395 @default.
• W2071181330 hasConceptScore W2071181330C54355233 @default.
• W2071181330 hasConceptScore W2071181330C86339819 @default.
• W2071181330 hasConceptScore W2071181330C86803240 @default.
• W2071181330 hasIssue "43" @default.
• W2071181330 hasLocation W20711813301 @default.
• W2071181330 hasLocation W20711813302 @default.
• W2071181330 hasLocation W20711813303 @default.
• W2071181330 hasLocation W20711813304 @default.
• W2071181330 hasLocation W20711813305 @default.
• W2071181330 hasOpenAccess W2071181330 @default.
• W2071181330 hasPrimaryLocation W20711813301 @default.
• W2071181330 hasRelatedWork W1968707958 @default.
• W2071181330 hasRelatedWork W1994150489 @default.
• W2071181330 hasRelatedWork W2002934916 @default.
• W2071181330 hasRelatedWork W2027476051 @default.
• W2071181330 hasRelatedWork W2063071041 @default.
• W2071181330 hasRelatedWork W2083232319 @default.
• W2071181330 hasRelatedWork W2089167440 @default.
• W2071181330 hasRelatedWork W2089315523 @default.
• W2071181330 hasRelatedWork W2095669369 @default.
• W2071181330 hasRelatedWork W2103156835 @default.
• W2071181330 hasRelatedWork W2109361919 @default.
• W2071181330 hasRelatedWork W2119795320 @default.
• W2071181330 hasRelatedWork W2120628024 @default.
• W2071181330 hasRelatedWork W2136206805 @default.
• W2071181330 hasRelatedWork W2159065029 @default.
• W2071181330 hasRelatedWork W2164836215 @default.
• W2071181330 hasRelatedWork W2329456180 @default.
• W2071181330 hasRelatedWork W2478742664 @default.
• W2071181330 hasRelatedWork W2801731255 @default.
• W2071181330 hasRelatedWork W3208019394 @default.
• W2071181330 hasVolume "109" @default.
• W2071181330 isParatext "false" @default.

• next