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• W2071214884 abstract "NMDA receptor (NMDAR)-dependent hippocampal synaptic plasticity underlying learning and memory coordinately regulates dendritic spine structure and AMPA receptor (AMPAR) postsynaptic strength through poorly understood mechanisms. Induction of long-term depression (LTD) activates protein phosphatase 2B/calcineurin (CaN), leading to dendritic spine shrinkage through actin depolymerization and AMPAR depression through receptor dephosphorylation and internalization. The scaffold proteins A-kinase-anchoring protein 79/150 (AKAP79/150) and postsynaptic density 95 (PSD95) form a complex that controls the opposing actions of the cAMP-dependent protein kinase (PKA) and CaN in regulation of AMPAR phosphorylation. The AKAP79/150-PSD95 complex is disrupted in hippocampal neurons during LTD coincident with internalization of AMPARs, decreases in PSD95 levels, and loss of AKAP79/150 and PKA from spines. AKAP79/150 is targeted to spines through binding F-actin and the phospholipid phosphatidylinositol-(4,5)-bisphosphate (PIP2). Previous electrophysiological studies have demonstrated that inhibition of phospholipase C (PLC)-catalyzed hydrolysis of PIP2 inhibits NMDAR-dependent LTD; however, the signaling mechanisms that link PLC activation to alterations in dendritic spine structure and AMPAR function in LTD are unknown. We show here that NMDAR stimulation of PLC in cultured hippocampal neurons is necessary for AKAP79/150 loss from spines and depolymerization of spine actin. Importantly, we demonstrate that NMDAR activation of PLC is also necessary for decreases in spine PSD95 levels and AMPAR internalization. Thus, PLC signaling is required for structural and functional changes in spine actin, PSD scaffolding, and AMPAR trafficking underlying postsynaptic expression of LTD." @default.
• W2071214884 created "2016-06-24" @default.
• W2071214884 creator A5002605353 @default.
• W2071214884 creator A5081464018 @default.
• W2071214884 date "2007-03-28" @default.
• W2071214884 modified "2023-10-10" @default.
• W2071214884 title "Phospholipase C Is Required for Changes in Postsynaptic Structure and Function Associated with NMDA Receptor-Dependent Long-Term Depression" @default.
• W2071214884 cites W1507515137 @default.
• W2071214884 cites W1557933310 @default.
• W2071214884 cites W1569092853 @default.
• W2071214884 cites W1570789308 @default.
• W2071214884 cites W1573292604 @default.
• W2071214884 cites W1606657325 @default.
• W2071214884 cites W1609834322 @default.
• W2071214884 cites W1796802340 @default.
• W2071214884 cites W1825094237 @default.
• W2071214884 cites W1834174605 @default.
• W2071214884 cites W1881079438 @default.
• W2071214884 cites W1964330366 @default.
• W2071214884 cites W1964945221 @default.
• W2071214884 cites W1969039665 @default.
• W2071214884 cites W1972970152 @default.
• W2071214884 cites W1973155317 @default.
• W2071214884 cites W1983553517 @default.
• W2071214884 cites W1986246328 @default.
• W2071214884 cites W1987055937 @default.
• W2071214884 cites W1991334194 @default.
• W2071214884 cites W1992939835 @default.
• W2071214884 cites W1993004513 @default.
• W2071214884 cites W1993135690 @default.
• W2071214884 cites W2003436719 @default.
• W2071214884 cites W2003729768 @default.
• W2071214884 cites W2011209444 @default.
• W2071214884 cites W2016425872 @default.
• W2071214884 cites W2016575029 @default.
• W2071214884 cites W2017842551 @default.
• W2071214884 cites W2021462093 @default.
• W2071214884 cites W2022513417 @default.
• W2071214884 cites W2027436298 @default.
• W2071214884 cites W2027557494 @default.
• W2071214884 cites W2027619860 @default.
• W2071214884 cites W2028363992 @default.
• W2071214884 cites W2035082265 @default.
• W2071214884 cites W2040653138 @default.
• W2071214884 cites W2050066016 @default.
• W2071214884 cites W2051323125 @default.
• W2071214884 cites W2054631039 @default.
• W2071214884 cites W2056491004 @default.
• W2071214884 cites W2056607057 @default.
• W2071214884 cites W2059890547 @default.
• W2071214884 cites W2061821373 @default.
• W2071214884 cites W2067859370 @default.
• W2071214884 cites W2069863147 @default.
• W2071214884 cites W2071885606 @default.
• W2071214884 cites W2073292915 @default.
• W2071214884 cites W2075805773 @default.
• W2071214884 cites W2076018512 @default.
• W2071214884 cites W2078797296 @default.
• W2071214884 cites W2082557512 @default.
• W2071214884 cites W2088239473 @default.
• W2071214884 cites W2088347772 @default.
• W2071214884 cites W2090116050 @default.
• W2071214884 cites W2091230743 @default.
• W2071214884 cites W2092281304 @default.
• W2071214884 cites W2092759474 @default.
• W2071214884 cites W2093807579 @default.
• W2071214884 cites W2096445692 @default.
• W2071214884 cites W2098107333 @default.
• W2071214884 cites W2101814309 @default.
• W2071214884 cites W2101875004 @default.
• W2071214884 cites W2106434831 @default.
• W2071214884 cites W2107611011 @default.
• W2071214884 cites W2109208582 @default.
• W2071214884 cites W2113913008 @default.
• W2071214884 cites W2114842668 @default.
• W2071214884 cites W2116450965 @default.
• W2071214884 cites W2116721774 @default.
• W2071214884 cites W2123298030 @default.
• W2071214884 cites W2128574573 @default.
• W2071214884 cites W2128802899 @default.
• W2071214884 cites W2130907973 @default.
• W2071214884 cites W2135290527 @default.
• W2071214884 cites W2148256023 @default.
• W2071214884 cites W2149381533 @default.
• W2071214884 cites W2151538478 @default.
• W2071214884 cites W2155715182 @default.
• W2071214884 cites W2162400338 @default.
• W2071214884 cites W2168319429 @default.
• W2071214884 cites W2168634382 @default.
• W2071214884 cites W2170532212 @default.
• W2071214884 cites W2267416220 @default.
• W2071214884 cites W4234071540 @default.
• W2071214884 doi "https://doi.org/10.1523/jneurosci.4340-06.2007" @default.
• W2071214884 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6672111" @default.
• W2071214884 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17392468" @default.
• W2071214884 hasPublicationYear "2007" @default.
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