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• W2071214930 endingPage "394" @default.
• W2071214930 startingPage "381" @default.
• W2071214930 abstract "The lack of a causal and successful treatment for sepsis has led to a re-evaluation of the condition's pathophysiology. The failure of anti-inflammatory strategies has implied compensatory immunosuppression to play a central part in fatal clinical cases. While searching for novel therapeutic strategies, the question arose whether pro-inflammation (systemic inflammatory response syndrome, SIRS) or anti-inflammation (compensatory anti-inflammatory response syndrome, CARS) are dominant in sepsis, and may be counteracted by therapeutic measures. Here we ask whether in a given organism--man or mouse--the lack of any functional protein involved in this cascade may help in understanding the events. In humans, genetic variations exist, and some of them have functional consequences altering the inflammatory response to pathogens. In mice, knockout animals were created, which may assist us in understanding the SIRS/CARS cascade. Here we summarize data on genetic variations in the TLR- and cytokine system and their influence on course of infectious diseases and sepsis. In addition, we summarize animal experiments and conclude that both cascades may be needed for containing infection. Imbalances in both the pro- and anti-inflammatory system may be harmful. Thus, interventional strategies have to be introduced carefully, and in the future genetic profiling may be needed in order to tailor therapies in the best way." @default.
• W2071214930 created "2016-06-24" @default.
• W2071214930 creator A5051684509 @default.
• W2071214930 creator A5053887656 @default.
• W2071214930 date "2010-01-01" @default.
• W2071214930 modified "2023-09-27" @default.
• W2071214930 title "Genetic Variation in Innate Immunity Pathways and Their Potential Contribution to the SIRS/CARS Debate: Evidence from Human Studies and Animal Models" @default.
• W2071214930 cites W1179544240 @default.
• W2071214930 cites W1487075065 @default.
• W2071214930 cites W1520365933 @default.
• W2071214930 cites W1570331116 @default.
• W2071214930 cites W1605072661 @default.
• W2071214930 cites W1648631879 @default.
• W2071214930 cites W1768438545 @default.
• W2071214930 cites W1912852347 @default.
• W2071214930 cites W1941687931 @default.
• W2071214930 cites W1942463334 @default.
• W2071214930 cites W1967269498 @default.
• W2071214930 cites W1967628584 @default.
• W2071214930 cites W1973449422 @default.
• W2071214930 cites W1977712559 @default.
• W2071214930 cites W1978926805 @default.
• W2071214930 cites W1980066425 @default.
• W2071214930 cites W1980220254 @default.
• W2071214930 cites W1981981738 @default.
• W2071214930 cites W1982663159 @default.
• W2071214930 cites W1991109223 @default.
• W2071214930 cites W1993947411 @default.
• W2071214930 cites W1995744610 @default.
• W2071214930 cites W1996120614 @default.
• W2071214930 cites W1998055077 @default.
• W2071214930 cites W2002295754 @default.
• W2071214930 cites W2003362321 @default.
• W2071214930 cites W2004067316 @default.
• W2071214930 cites W2004487653 @default.
• W2071214930 cites W2008261126 @default.
• W2071214930 cites W2009550948 @default.
• W2071214930 cites W2013856377 @default.
• W2071214930 cites W2016132912 @default.
• W2071214930 cites W2019277327 @default.
• W2071214930 cites W2020969008 @default.
• W2071214930 cites W2023133657 @default.
• W2071214930 cites W2024133296 @default.
• W2071214930 cites W2024418426 @default.
• W2071214930 cites W2026981701 @default.
• W2071214930 cites W2029887388 @default.
• W2071214930 cites W2031679095 @default.
• W2071214930 cites W2035454589 @default.
• W2071214930 cites W2036169141 @default.
• W2071214930 cites W2038486513 @default.
• W2071214930 cites W2040642611 @default.
• W2071214930 cites W2041977750 @default.
• W2071214930 cites W2042474497 @default.
• W2071214930 cites W2046855686 @default.
• W2071214930 cites W2050413576 @default.
• W2071214930 cites W2053267305 @default.
• W2071214930 cites W2055737465 @default.
• W2071214930 cites W2058113350 @default.
• W2071214930 cites W2060034321 @default.
• W2071214930 cites W2063953590 @default.
• W2071214930 cites W2067761476 @default.
• W2071214930 cites W2069092884 @default.
• W2071214930 cites W2079517510 @default.
• W2071214930 cites W2084149236 @default.
• W2071214930 cites W2084474700 @default.
• W2071214930 cites W2088946209 @default.
• W2071214930 cites W2092713838 @default.
• W2071214930 cites W2095668509 @default.
• W2071214930 cites W2096743939 @default.
• W2071214930 cites W2103336162 @default.
• W2071214930 cites W2103553417 @default.
• W2071214930 cites W2105617732 @default.
• W2071214930 cites W2105981152 @default.
• W2071214930 cites W2107348873 @default.
• W2071214930 cites W2107513722 @default.
• W2071214930 cites W2107762058 @default.
• W2071214930 cites W2110853277 @default.
• W2071214930 cites W2112223832 @default.
• W2071214930 cites W2114216755 @default.
• W2071214930 cites W2114922744 @default.
• W2071214930 cites W2115135651 @default.
• W2071214930 cites W2115922864 @default.
• W2071214930 cites W2122138110 @default.
• W2071214930 cites W2125279861 @default.
• W2071214930 cites W2127988591 @default.
• W2071214930 cites W2130421133 @default.
• W2071214930 cites W2132413368 @default.
• W2071214930 cites W2134875821 @default.
• W2071214930 cites W2137082708 @default.
• W2071214930 cites W2138049915 @default.
• W2071214930 cites W2138107401 @default.
• W2071214930 cites W2141040025 @default.
• W2071214930 cites W2141380939 @default.
• W2071214930 cites W2144136875 @default.
• W2071214930 cites W2144152742 @default.
• W2071214930 cites W2144301584 @default.
• W2071214930 cites W2144824088 @default.
• W2071214930 cites W2145564764 @default.

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