FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2071217288> ?p ?o ?g. }

• W2071217288 endingPage "2252" @default.
• W2071217288 startingPage "2240" @default.
• W2071217288 abstract "Spatial organisation and trafficking of endocytic organelles in mammalian cells is tightly regulated and dependent on cytoskeletal networks. The dynamics of endocytic pathways is modified in a number of diseases, including cancer, and notably in multidrug resistant (MDR) cells that are refractory to the effects of several anti-cancer agents. These cells often upregulate expression of drug-efflux pumps but this may be synergistic with alternative resistance mechanisms including increased acidification of endocytic organelles that enhances vesicular sequestration of weak-base anti-cancer drugs such as daunorubicin away from their nuclear target. Here, we characterised the distribution of sequestered daunorubicin in commonly used leukaemia cell lines, HL-60, K562, KG1a and the multidrug resistant HL-60/ADR line, and related this to the spatial distribution of their endocytic organelles and microtubule networks. HL-60 and KG1a cells contained microtubule arrays emanating from organising centres, and their endocytic organelles and daunorubicin labelled vesicles were scattered throughout the cytoplasm. HL-60/ADR and K562 cells showed extensive clustering of early and recycling endosomes, late endosomes, lysosomes and daunorubicin to a juxtanuclear region but these cells lacked microtubule arrays. Microtubular organisation within these clustered regions was however, required for spatial tethering of endocytic organelles and the Golgi, as treatment with nocodazole and paclitaxel had major effects on their distribution. HL-60 and HL-60/ADR cells had similar lysosomal pH of <5.0 and overall these findings suggests a general relationship between the absence of microtubule arrays and the propensity of leukaemia cell lines to cluster endocytic organelles and daunorubicin into the juxtanuclear region." @default.
• W2071217288 created "2016-06-24" @default.
• W2071217288 creator A5050585535 @default.
• W2071217288 creator A5063083430 @default.
• W2071217288 creator A5067076637 @default.
• W2071217288 creator A5082156574 @default.
• W2071217288 date "2008-01-01" @default.
• W2071217288 modified "2023-09-27" @default.
• W2071217288 title "Clustering of endocytic organelles in parental and drug-resistant myeloid leukaemia cell lines lacking centrosomally organised microtubule arrays" @default.
• W2071217288 cites W100823820 @default.
• W2071217288 cites W1521233708 @default.
• W2071217288 cites W1582548909 @default.
• W2071217288 cites W1966463888 @default.
• W2071217288 cites W1968444384 @default.
• W2071217288 cites W1985113094 @default.
• W2071217288 cites W2004861990 @default.
• W2071217288 cites W2005866145 @default.
• W2071217288 cites W2010183849 @default.
• W2071217288 cites W2014649329 @default.
• W2071217288 cites W2024532487 @default.
• W2071217288 cites W2029843133 @default.
• W2071217288 cites W2032082931 @default.
• W2071217288 cites W2040246951 @default.
• W2071217288 cites W2043909845 @default.
• W2071217288 cites W2047316426 @default.
• W2071217288 cites W2048868723 @default.
• W2071217288 cites W2057645194 @default.
• W2071217288 cites W2059015272 @default.
• W2071217288 cites W2060650464 @default.
• W2071217288 cites W2068474659 @default.
• W2071217288 cites W2073055302 @default.
• W2071217288 cites W2081097779 @default.
• W2071217288 cites W2081305073 @default.
• W2071217288 cites W2093657739 @default.
• W2071217288 cites W2095329950 @default.
• W2071217288 cites W2095874199 @default.
• W2071217288 cites W2096535122 @default.
• W2071217288 cites W2103526907 @default.
• W2071217288 cites W2110408216 @default.
• W2071217288 cites W2114526467 @default.
• W2071217288 cites W2133253871 @default.
• W2071217288 cites W2134344512 @default.
• W2071217288 cites W2144692413 @default.
• W2071217288 cites W2164272102 @default.
• W2071217288 cites W2167806590 @default.
• W2071217288 cites W258442487 @default.
• W2071217288 doi "https://doi.org/10.1016/j.biocel.2008.03.004" @default.
• W2071217288 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18439867" @default.
• W2071217288 hasPublicationYear "2008" @default.
• W2071217288 type Work @default.
• W2071217288 sameAs 2071217288 @default.
• W2071217288 citedByCount "7" @default.
• W2071217288 countsByYear W20712172882013 @default.
• W2071217288 countsByYear W20712172882017 @default.
• W2071217288 countsByYear W20712172882020 @default.
• W2071217288 countsByYear W20712172882021 @default.
• W2071217288 countsByYear W20712172882022 @default.
• W2071217288 crossrefType "journal-article" @default.
• W2071217288 hasAuthorship W2071217288A5050585535 @default.
• W2071217288 hasAuthorship W2071217288A5063083430 @default.
• W2071217288 hasAuthorship W2071217288A5067076637 @default.
• W2071217288 hasAuthorship W2071217288A5082156574 @default.
• W2071217288 hasConcept C102747710 @default.
• W2071217288 hasConcept C119062480 @default.
• W2071217288 hasConcept C142669718 @default.
• W2071217288 hasConcept C1491633281 @default.
• W2071217288 hasConcept C158617107 @default.
• W2071217288 hasConcept C168240541 @default.
• W2071217288 hasConcept C20418707 @default.
• W2071217288 hasConcept C2778461978 @default.
• W2071217288 hasConcept C2779363559 @default.
• W2071217288 hasConcept C2781021840 @default.
• W2071217288 hasConcept C28005876 @default.
• W2071217288 hasConcept C54355233 @default.
• W2071217288 hasConcept C55493867 @default.
• W2071217288 hasConcept C79747257 @default.
• W2071217288 hasConcept C79879829 @default.
• W2071217288 hasConcept C86803240 @default.
• W2071217288 hasConcept C95444343 @default.
• W2071217288 hasConceptScore W2071217288C102747710 @default.
• W2071217288 hasConceptScore W2071217288C119062480 @default.
• W2071217288 hasConceptScore W2071217288C142669718 @default.
• W2071217288 hasConceptScore W2071217288C1491633281 @default.
• W2071217288 hasConceptScore W2071217288C158617107 @default.
• W2071217288 hasConceptScore W2071217288C168240541 @default.
• W2071217288 hasConceptScore W2071217288C20418707 @default.
• W2071217288 hasConceptScore W2071217288C2778461978 @default.
• W2071217288 hasConceptScore W2071217288C2779363559 @default.
• W2071217288 hasConceptScore W2071217288C2781021840 @default.
• W2071217288 hasConceptScore W2071217288C28005876 @default.
• W2071217288 hasConceptScore W2071217288C54355233 @default.
• W2071217288 hasConceptScore W2071217288C55493867 @default.
• W2071217288 hasConceptScore W2071217288C79747257 @default.
• W2071217288 hasConceptScore W2071217288C79879829 @default.
• W2071217288 hasConceptScore W2071217288C86803240 @default.
• W2071217288 hasConceptScore W2071217288C95444343 @default.
• W2071217288 hasIssue "10" @default.
• W2071217288 hasLocation W20712172881 @default.

• next