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- W2071250101 abstract "Abstract Since their discovery as key mediators of cytokine signaling, considerable progress has been made in understanding the structure and function of Signal Transducers and Activators of Transcriptions (STATs). In addition to their central roles in normal cell signaling, recent studies have demonstrated that diverse oncoproteins can activate specific STATs (particularly Stat3 and Stat5) and that constitutively-activated STAT signaling directly contributes to oncogenesis. Furthermore, extensive surveys of primary tumors and cell lines derived from tumors indicate that inappropriate activation of specific STATs occurs with surprisingly high frequency in wide variety of human cancers, including numerous blood malignancies. In particular, these findings provide compelling evidence that aberrant STAT activation contributes to the process of malignant transformation in multiple myeloma, leukemias and lymphomas. These studies are beginning to reveal the molecular mechanisms leading to STAT activation in the context of oncogenesis, and candidate genes regulated by STATs that may contribute to oncogenesis are being identified. Recent studies suggest that activated STAT signaling participates in oncogenesis by stimulating cell proliferation and preventing apoptosis. The critical roles of STATs in oncogenesis identify these proteins as novel molecular targets for development of potential new therapies against multiple myeloma, leukemias and lymphomas." @default.
- W2071250101 created "2016-06-24" @default.
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- W2071250101 date "2000-07-01" @default.
- W2071250101 modified "2023-09-26" @default.
- W2071250101 title "Role of aberrant stat signaling in blood malignancies" @default.
- W2071250101 doi "https://doi.org/10.1016/s0301-472x(00)00502-6" @default.
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