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• W2071279551 startingPage "e12845" @default.
• W2071279551 abstract "Background The mammalian target of rapamycin (mTOR) is an evolutionarily conserved Ser/Thr protein kinase that plays a pivotal role in multiple fundamental biological processes, including synaptic plasticity. We explored the relationship between the mTOR pathway and β-amyloid (Aβ)-induced synaptic dysfunction, which is considered to be critical in the pathogenesis of Alzheimer's disease (AD). Methodology/Principal Findings We provide evidence that inhibition of mTOR signaling correlates with impairment in synaptic plasticity in hippocampal slices from an AD mouse model and in wild-type slices exposed to exogenous Aβ1-42. Importantly, by up-regulating mTOR signaling, glycogen synthase kinase 3 (GSK3) inhibitors rescued LTP in the AD mouse model, and genetic deletion of FK506-binding protein 12 (FKBP12) prevented Aβ-induced impairment in long-term potentiation (LTP). In addition, confocal microscopy demonstrated co-localization of intraneuronal Aβ42 with mTOR. Conclusions/Significance These data support the notion that the mTOR pathway modulates Aβ-related synaptic dysfunction in AD." @default.
• W2071279551 created "2016-06-24" @default.
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• W2071279551 date "2010-09-20" @default.
• W2071279551 modified "2023-10-17" @default.
• W2071279551 title "Dysregulation of the mTOR Pathway Mediates Impairment of Synaptic Plasticity in a Mouse Model of Alzheimer's Disease" @default.
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• W2071279551 doi "https://doi.org/10.1371/journal.pone.0012845" @default.
• W2071279551 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2942840" @default.
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