FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2071291247> ?p ?o ?g. }

• W2071291247 endingPage "838" @default.
• W2071291247 startingPage "832" @default.
• W2071291247 abstract "Abstract Background and Aim: Immunosuppressive therapy may precipitate Clostridium difficile associated disease (CDAD). We evaluated the role of cyclosporin in the development of CDAD in the experimental mouse model and studied the effect of probiotic and epidermal growth factor (EGF) as biotherapeutics measures. Methods: BALB/c mice ( n = 24) were divided into four groups. Group I animals not given any inoculum served as controls. Animals in the remaining three groups (Group II, III and IV) were given cyclosporin daily from days 1–7 followed by C. difficile inoculum on day 8. Additionally, the animals received Lactobacillus acidophilus (Group III) and EGF (Group IV) for one‐week post C. difficile challenge. The animals were evaluated for colonization and toxin production by C. difficile , myeloperoxidase (MPO) activity and histopathological changes. Results: Clostridium difficile was colonized and elaborated its toxins in animals receiving cyclosporin and C. difficile . MPO activity was significantly higher ( P < 0.05) and histopathological epithelial damage, cryptitis and acute inflammatory changes were seen in the cecum and colon. C. difficile count, toxins A and B titers and MPO activity were significantly lowered ( P < 0.05) in animals receiving probiotic and EGF. Histopathologically, mucodepletion and inflammatory infiltrate were decreased in the biotherapeutic receiving animals. Conclusions: Cyclosporin led to the development of mild to moderate CDAD in animals. Administration of biotherapeutics reduced the severity of CDAD. Future clinical trials are needed for further investigation of these potential biotherapeutic measures." @default.
• W2071291247 created "2016-06-24" @default.
• W2071291247 creator A5003430702 @default.
• W2071291247 creator A5023720983 @default.
• W2071291247 creator A5027900775 @default.
• W2071291247 creator A5031816199 @default.
• W2071291247 creator A5061844645 @default.
• W2071291247 date "2010-03-25" @default.
• W2071291247 modified "2023-10-16" @default.
• W2071291247 title "Effect of biotherapeutics on cyclosporin-induced<i>Clostridium difficile</i>infection in mice" @default.
• W2071291247 cites W131339407 @default.
• W2071291247 cites W1491994559 @default.
• W2071291247 cites W1644493627 @default.
• W2071291247 cites W1775749144 @default.
• W2071291247 cites W1942111791 @default.
• W2071291247 cites W1961388096 @default.
• W2071291247 cites W1980953294 @default.
• W2071291247 cites W1988112148 @default.
• W2071291247 cites W1989599580 @default.
• W2071291247 cites W1994474958 @default.
• W2071291247 cites W1997329933 @default.
• W2071291247 cites W2011669490 @default.
• W2071291247 cites W2013222094 @default.
• W2071291247 cites W2020358486 @default.
• W2071291247 cites W2031610915 @default.
• W2071291247 cites W2040796902 @default.
• W2071291247 cites W2041613596 @default.
• W2071291247 cites W2048840825 @default.
• W2071291247 cites W2051131215 @default.
• W2071291247 cites W2082598330 @default.
• W2071291247 cites W2091900082 @default.
• W2071291247 cites W2099599782 @default.
• W2071291247 cites W2099783944 @default.
• W2071291247 cites W2111037277 @default.
• W2071291247 cites W2111976364 @default.
• W2071291247 cites W2120393841 @default.
• W2071291247 cites W2130150046 @default.
• W2071291247 cites W2133439029 @default.
• W2071291247 cites W2139150280 @default.
• W2071291247 cites W2143782107 @default.
• W2071291247 cites W2143849824 @default.
• W2071291247 cites W2155046943 @default.
• W2071291247 cites W2164022200 @default.
• W2071291247 cites W2167766152 @default.
• W2071291247 cites W2318911370 @default.
• W2071291247 cites W2341427843 @default.
• W2071291247 cites W2414315952 @default.
• W2071291247 cites W4211184309 @default.
• W2071291247 cites W4250825672 @default.
• W2071291247 cites W4319053778 @default.
• W2071291247 doi "https://doi.org/10.1111/j.1440-1746.2009.06135.x" @default.
• W2071291247 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20074161" @default.
• W2071291247 hasPublicationYear "2010" @default.
• W2071291247 type Work @default.
• W2071291247 sameAs 2071291247 @default.
• W2071291247 citedByCount "14" @default.
• W2071291247 countsByYear W20712912472012 @default.
• W2071291247 countsByYear W20712912472014 @default.
• W2071291247 countsByYear W20712912472015 @default.
• W2071291247 countsByYear W20712912472016 @default.
• W2071291247 countsByYear W20712912472017 @default.
• W2071291247 crossrefType "journal-article" @default.
• W2071291247 hasAuthorship W2071291247A5003430702 @default.
• W2071291247 hasAuthorship W2071291247A5023720983 @default.
• W2071291247 hasAuthorship W2071291247A5027900775 @default.
• W2071291247 hasAuthorship W2071291247A5031816199 @default.
• W2071291247 hasAuthorship W2071291247A5061844645 @default.
• W2071291247 hasConcept C126322002 @default.
• W2071291247 hasConcept C203014093 @default.
• W2071291247 hasConcept C203565725 @default.
• W2071291247 hasConcept C2776914184 @default.
• W2071291247 hasConcept C2777221637 @default.
• W2071291247 hasConcept C2777507495 @default.
• W2071291247 hasConcept C2780255968 @default.
• W2071291247 hasConcept C2781092032 @default.
• W2071291247 hasConcept C2994496256 @default.
• W2071291247 hasConcept C501593827 @default.
• W2071291247 hasConcept C523546767 @default.
• W2071291247 hasConcept C54355233 @default.
• W2071291247 hasConcept C71924100 @default.
• W2071291247 hasConcept C86803240 @default.
• W2071291247 hasConcept C89423630 @default.
• W2071291247 hasConcept C90924648 @default.
• W2071291247 hasConcept C97505648 @default.
• W2071291247 hasConcept C98274493 @default.
• W2071291247 hasConceptScore W2071291247C126322002 @default.
• W2071291247 hasConceptScore W2071291247C203014093 @default.
• W2071291247 hasConceptScore W2071291247C203565725 @default.
• W2071291247 hasConceptScore W2071291247C2776914184 @default.
• W2071291247 hasConceptScore W2071291247C2777221637 @default.
• W2071291247 hasConceptScore W2071291247C2777507495 @default.
• W2071291247 hasConceptScore W2071291247C2780255968 @default.
• W2071291247 hasConceptScore W2071291247C2781092032 @default.
• W2071291247 hasConceptScore W2071291247C2994496256 @default.
• W2071291247 hasConceptScore W2071291247C501593827 @default.
• W2071291247 hasConceptScore W2071291247C523546767 @default.
• W2071291247 hasConceptScore W2071291247C54355233 @default.
• W2071291247 hasConceptScore W2071291247C71924100 @default.

• next