FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2071294281> ?p ?o ?g. }

• W2071294281 endingPage "A419" @default.
• W2071294281 startingPage "A418" @default.
• W2071294281 abstract "To investigate the cross-over effects on health-related quality of life (HRQoL) in an randomized cross-over design study for hemophilia-A patients. HRQoL via SF-36 Health Survey was measured every 3 months in a prospective, randomized, cross-over, investigator-initiated study comparing 6 months of AICC infused prophylaxis (PX) with 6 months of on-demand (OD) therapy, separated by a 3-month washout period during which patients used on-demand therapy. HRQoL was summarized in two continuous variables: Physical Component Score (PCS-36) and Mental Component Score (MCS-36). The difference between two study periods for 6-month change from baseline in PCS-/MCS-36 are compared using Wilcoxon signed-rank test to measure the difference between two groups regardless of the sequence of medications. To investigate the effect of random sequence in the change of HRQoL, the difference between two study periods for 6-month change from baseline in PCS-/MCS-36 is compared by random sequence using Wilcoxon-Mann-Whitney U test with exact statement. Twenty-six patients completed both study periods. 17 of them were >14 years old and thus completed QoL questionnaires and are included in this analysis. The difference between PX and OD in 6-month change from baseline was 2.83 for PCS-36 (p=0.378) and 1.29 for MCS-36 (p=0.890), favored PX on both measures. Regardless of random sequence of medication, HRQoL showed a moderate improvement with PX. When comparing the difference of 6-month change by treatment sequence, patients who initiated with PX then switched to OD had a greater improvement compared to the opposite sequence (PX->OD: 6.59, OD->PX: 0.19 for PCS-36 (p=0.475); PX→OD: 2.66, OD→PX: 0.33 for MCS-36 (p=0.601)). A cross-over effect, albeit statistically non-significant, was observed when the difference of 6-month change was compared by treatment sequence. Patients who started with more favorable medication tended to show a greater improvement, whereas patients in opposite sequence showed a slight improvement." @default.
• W2071294281 created "2016-06-24" @default.
• W2071294281 creator A5012371110 @default.
• W2071294281 creator A5036470440 @default.
• W2071294281 creator A5036479504 @default.
• W2071294281 creator A5041329419 @default.
• W2071294281 creator A5049126558 @default.
• W2071294281 creator A5080646091 @default.
• W2071294281 date "2011-11-01" @default.
• W2071294281 modified "2023-09-26" @default.
• W2071294281 title "PSY47 Evaluating the Cross-over Effect on Health-related Quality of Life in a Randomized Cross-over Study of Hemophilia-A Patients" @default.
• W2071294281 doi "https://doi.org/10.1016/j.jval.2011.08.1019" @default.
• W2071294281 hasPublicationYear "2011" @default.
• W2071294281 type Work @default.
• W2071294281 sameAs 2071294281 @default.
• W2071294281 citedByCount "1" @default.
• W2071294281 countsByYear W20712942812021 @default.
• W2071294281 crossrefType "journal-article" @default.
• W2071294281 hasAuthorship W2071294281A5012371110 @default.
• W2071294281 hasAuthorship W2071294281A5036470440 @default.
• W2071294281 hasAuthorship W2071294281A5036479504 @default.
• W2071294281 hasAuthorship W2071294281A5041329419 @default.
• W2071294281 hasAuthorship W2071294281A5049126558 @default.
• W2071294281 hasAuthorship W2071294281A5080646091 @default.
• W2071294281 hasBestOaLocation W20712942811 @default.
• W2071294281 hasConcept C111278954 @default.
• W2071294281 hasConcept C126322002 @default.
• W2071294281 hasConcept C12868164 @default.
• W2071294281 hasConcept C159110408 @default.
• W2071294281 hasConcept C168563851 @default.
• W2071294281 hasConcept C1862650 @default.
• W2071294281 hasConcept C206041023 @default.
• W2071294281 hasConcept C2779134260 @default.
• W2071294281 hasConcept C2779951463 @default.
• W2071294281 hasConcept C3019006561 @default.
• W2071294281 hasConcept C71924100 @default.
• W2071294281 hasConceptScore W2071294281C111278954 @default.
• W2071294281 hasConceptScore W2071294281C126322002 @default.
• W2071294281 hasConceptScore W2071294281C12868164 @default.
• W2071294281 hasConceptScore W2071294281C159110408 @default.
• W2071294281 hasConceptScore W2071294281C168563851 @default.
• W2071294281 hasConceptScore W2071294281C1862650 @default.
• W2071294281 hasConceptScore W2071294281C206041023 @default.
• W2071294281 hasConceptScore W2071294281C2779134260 @default.
• W2071294281 hasConceptScore W2071294281C2779951463 @default.
• W2071294281 hasConceptScore W2071294281C3019006561 @default.
• W2071294281 hasConceptScore W2071294281C71924100 @default.
• W2071294281 hasIssue "7" @default.
• W2071294281 hasLocation W20712942811 @default.
• W2071294281 hasOpenAccess W2071294281 @default.
• W2071294281 hasPrimaryLocation W20712942811 @default.
• W2071294281 hasRelatedWork W2013136801 @default.
• W2071294281 hasRelatedWork W2028197737 @default.
• W2071294281 hasRelatedWork W2071294281 @default.
• W2071294281 hasRelatedWork W2105435501 @default.
• W2071294281 hasRelatedWork W2724536751 @default.
• W2071294281 hasRelatedWork W2788878166 @default.
• W2071294281 hasRelatedWork W2973108776 @default.
• W2071294281 hasRelatedWork W2985064377 @default.
• W2071294281 hasRelatedWork W2999221991 @default.
• W2071294281 hasRelatedWork W3116028462 @default.
• W2071294281 hasVolume "14" @default.
• W2071294281 isParatext "false" @default.
• W2071294281 isRetracted "false" @default.
• W2071294281 magId "2071294281" @default.
• W2071294281 workType "article" @default.