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• W2071303676 abstract "Pulse wave velocity (PWV), an established index of arterial compliance, has been shown in adults to be strongly associated with the presence and extent of atherosclerosis. PWV is the strongest predictor of CV mortality. We sought in a pilot study to establish normal values of brachial-ankle PWV (baPWV) in a group of 48 normotensive, healthy youths with BMI < 75% for age. The group consisted of 26 African-American (AA) and 22 Caucasian (C) subjects ages 12–18 yrs from a metropolitan area in the southern US. Measurements were performed using a previously validated protocol with the Colin Medical Instruments VP-1000 Vascular Profiling System. Each subject's baPWV was defined as the average of two consecutive measurements obtained supine after at least five minutes of rest. All data are reported as mean +/- SD. The baPWV of our subjects was 10.4 +/- 1.45 m/s. The mean age was 15.1 yrs. A study by Avolio, et al. of PWV measurements in age-matched (mean 15.5 yrs), normotensive, healthy Chinese subjects has found PWV values of 6.32 +/- 0.62 m/s. Our subjects’ values were markedly higher than those youth, p<0.0001 (95% CI 3.62 to 4.52). When the US subjects were separated by ethnicity the mean PWV of AA subjects tended to be higher (10.7 +/- 1.3 m/s [SD] vs. 10.0 +/- 1.5 m/s) than C, though not yet statistically significant (p< 0.1). PWV in the composite US group was significantly higher when compared with the Chinese group. This marked difference suggests that in a normotensive, healthy population where the incidence of coronary artery disease, type 2 diabetes, hypertension, and obesity are much higher in adulthood, vascular changes commensurate with those diseases are already occurring and demonstrable early in life. In addition, although not yet statistically significant, the difference in AA and C measurements suggests that there may be a racial difference in PWV. To define whether a difference exists between AA and C during teenage years we are currently performing a larger study to include 75 normal weight (BMI< 75% for age) subjects per ethnic group, the number of subjects required by a power analysis to achieve statistical significance. Additionally, we are performing another study to include 50 overweight (BMI > 95% for age) subjects per ethnic group to determine the effect of overweight on PWV." @default.
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• W2071303676 date "2005-05-01" @default.
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• W2071303676 title "Pulse wave velocity in normotensive healthy southern US youth" @default.
• W2071303676 doi "https://doi.org/10.1016/j.amjhyper.2005.03.025" @default.
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