FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2071303774> ?p ?o ?g. }

• W2071303774 endingPage "892" @default.
• W2071303774 startingPage "886" @default.
• W2071303774 abstract "Abstract In a double-blind, randomized, crossover study, we investigated in 15 healthy male volunteers the effects of recombinant (r-) hirudin (HBW 023, 0.35 mg/kg body wt SC), unfractionated heparin (UFH, HeparinNovo; 150 IU/kg body wt SC), and a low-molecular-weight heparin preparation (LMWH, Fragmin; 75 IU/kg body wt SC) on coagulation and platelet activation in vivo by measuring specific coagulation-activation peptides (prothrombin fragment 1+2 [F1+2], thrombin–antithrombin-III complex [TAT], and β-thromboglobulin [β-TG]) in bleeding-time blood (activated state) and venous blood (basal state). In bleeding-time blood, r-hirudin and the heparin preparations significantly inhibited formation of both TAT and F1+2. However, the inhibitory effect of r-hirudin on F1+2 generation was short-lived and weaker compared with that of UFH and LMWH, and the TAT-to-F1+2 ratio was significantly lower after r-hirudin than after UFH or LMWH. Thus, in vivo, when the coagulation system is in an activated state, r-hirudin exerts its anticoagulant effects predominantly by inhibiting thrombin (factor IIa), whereas UFH and LMWH are directed against both factors Xa and IIa. A different mode of action for UFH and LMWH was not detectable. In venous blood, r-hirudin caused a moderate reduction in TAT formation and an increase (at 1 hour) rather than a decrease in F1+2 generation. Formation of TAT and F1+2 was suppressed at various time points following both UFH and LMWH. There was no difference in the TAT-to-F1+2 ratio after r-hirudin and heparin. Thus, a predominant effect of r-hirudin on factor IIa (as found in bleeding-time blood) was not detectable in venous blood. In bleeding-time blood, r-hirudin (but neither UFH nor LMWH) significantly inhibited β-TG release. In contrast, both UFH and LMWH caused an increase in β-TG 10 hours after heparin administration. Our observation of reduced platelet function after r-hirudin compared with delayed platelet activation following UFH and LMWH suggests an advantage of r-hirudin over heparin, especially in those clinical situations (such as arterial thromboembolism) where enhanced platelet activity has been shown to be of particular importance." @default.
• W2071303774 created "2016-06-24" @default.
• W2071303774 creator A5053093013 @default.
• W2071303774 creator A5054404247 @default.
• W2071303774 creator A5056162322 @default.
• W2071303774 creator A5060041875 @default.
• W2071303774 creator A5065325813 @default.
• W2071303774 creator A5067571671 @default.
• W2071303774 creator A5070752127 @default.
• W2071303774 creator A5083779043 @default.
• W2071303774 date "1995-07-01" @default.
• W2071303774 modified "2023-10-14" @default.
• W2071303774 title "Effects of Recombinant Hirudin (r-Hirudin, HBW 023) on Coagulation and Platelet Activation In Vivo" @default.
• W2071303774 cites W1489050099 @default.
• W2071303774 cites W1530591019 @default.
• W2071303774 cites W1966682207 @default.
• W2071303774 cites W1978576543 @default.
• W2071303774 cites W1983460136 @default.
• W2071303774 cites W1985025725 @default.
• W2071303774 cites W2000464298 @default.
• W2071303774 cites W2036009604 @default.
• W2071303774 cites W2044880765 @default.
• W2071303774 cites W2050762244 @default.
• W2071303774 cites W2051309368 @default.
• W2071303774 cites W2085223950 @default.
• W2071303774 cites W2088153339 @default.
• W2071303774 cites W2112799238 @default.
• W2071303774 cites W2338618131 @default.
• W2071303774 cites W2396160366 @default.
• W2071303774 cites W2411893053 @default.
• W2071303774 cites W2473782998 @default.
• W2071303774 cites W2994208559 @default.
• W2071303774 cites W3151469085 @default.
• W2071303774 cites W342169260 @default.
• W2071303774 cites W84205322 @default.
• W2071303774 cites W86417293 @default.
• W2071303774 doi "https://doi.org/10.1161/01.atv.15.7.886" @default.
• W2071303774 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7600120" @default.
• W2071303774 hasPublicationYear "1995" @default.
• W2071303774 type Work @default.
• W2071303774 sameAs 2071303774 @default.
• W2071303774 citedByCount "19" @default.
• W2071303774 countsByYear W20713037742014 @default.
• W2071303774 countsByYear W20713037742016 @default.
• W2071303774 crossrefType "journal-article" @default.
• W2071303774 hasAuthorship W2071303774A5053093013 @default.
• W2071303774 hasAuthorship W2071303774A5054404247 @default.
• W2071303774 hasAuthorship W2071303774A5056162322 @default.
• W2071303774 hasAuthorship W2071303774A5060041875 @default.
• W2071303774 hasAuthorship W2071303774A5065325813 @default.
• W2071303774 hasAuthorship W2071303774A5067571671 @default.
• W2071303774 hasAuthorship W2071303774A5070752127 @default.
• W2071303774 hasAuthorship W2071303774A5083779043 @default.
• W2071303774 hasConcept C126322002 @default.
• W2071303774 hasConcept C150903083 @default.
• W2071303774 hasConcept C185592680 @default.
• W2071303774 hasConcept C203014093 @default.
• W2071303774 hasConcept C207001950 @default.
• W2071303774 hasConcept C2777292125 @default.
• W2071303774 hasConcept C2777557582 @default.
• W2071303774 hasConcept C2778205648 @default.
• W2071303774 hasConcept C2778271848 @default.
• W2071303774 hasConcept C2778382381 @default.
• W2071303774 hasConcept C2779026020 @default.
• W2071303774 hasConcept C3018697912 @default.
• W2071303774 hasConcept C55493867 @default.
• W2071303774 hasConcept C71924100 @default.
• W2071303774 hasConcept C86803240 @default.
• W2071303774 hasConcept C89560881 @default.
• W2071303774 hasConcept C98274493 @default.
• W2071303774 hasConceptScore W2071303774C126322002 @default.
• W2071303774 hasConceptScore W2071303774C150903083 @default.
• W2071303774 hasConceptScore W2071303774C185592680 @default.
• W2071303774 hasConceptScore W2071303774C203014093 @default.
• W2071303774 hasConceptScore W2071303774C207001950 @default.
• W2071303774 hasConceptScore W2071303774C2777292125 @default.
• W2071303774 hasConceptScore W2071303774C2777557582 @default.
• W2071303774 hasConceptScore W2071303774C2778205648 @default.
• W2071303774 hasConceptScore W2071303774C2778271848 @default.
• W2071303774 hasConceptScore W2071303774C2778382381 @default.
• W2071303774 hasConceptScore W2071303774C2779026020 @default.
• W2071303774 hasConceptScore W2071303774C3018697912 @default.
• W2071303774 hasConceptScore W2071303774C55493867 @default.
• W2071303774 hasConceptScore W2071303774C71924100 @default.
• W2071303774 hasConceptScore W2071303774C86803240 @default.
• W2071303774 hasConceptScore W2071303774C89560881 @default.
• W2071303774 hasConceptScore W2071303774C98274493 @default.
• W2071303774 hasIssue "7" @default.
• W2071303774 hasLocation W20713037741 @default.
• W2071303774 hasLocation W20713037742 @default.
• W2071303774 hasOpenAccess W2071303774 @default.
• W2071303774 hasPrimaryLocation W20713037741 @default.
• W2071303774 hasRelatedWork W1609193188 @default.
• W2071303774 hasRelatedWork W2000164647 @default.
• W2071303774 hasRelatedWork W2005112291 @default.
• W2071303774 hasRelatedWork W2012211687 @default.
• W2071303774 hasRelatedWork W2067826050 @default.
• W2071303774 hasRelatedWork W2077232244 @default.

• next