Matches in SemOpenAlex for { <https://semopenalex.org/work/W2071305174> ?p ?o ?g. }
- W2071305174 endingPage "212" @default.
- W2071305174 startingPage "201" @default.
- W2071305174 abstract "Peroxisome proliferators are a class of structurally diverse chemicals, which induce liver carcinogenesis in rodents through interaction and activation of the Peroxisome Proliferator-Activated Receptor alpha (PPARalpha). PPARalpha agonists elicit a powerful pleiotropic response, which include hypolipidaemia. We have examined the response of species that are classically unresponsive to peroxisome proliferators. Whereas hamster responds to PPARalpha agonists by hepatomegaly and induction of marker genes, the guinea pig does not undergo hepatomegaly or induction of marker genes, such as CYP4A13. Both the hamster and the guinea pig have PPARalpha, and the guinea pig receptor has been characterised to be fully functional, as demonstrated in reporter gene expression assays. However, the guinea pig PPARalpha is expressed at low levels in liver, and the currently favoured hypothesis to explain species differences in hepatic peroxisome proliferation invokes the low level of PPARalpha as the principal determinant of species responsiveness. However, the demonstration that guinea pigs and humans undergo hypolipidaemia induced by PPARalpha-agonists calls into question the mode of action of PPARalpha agonists in non-responsive species." @default.
- W2071305174 created "2016-06-24" @default.
- W2071305174 creator A5028138093 @default.
- W2071305174 creator A5043334356 @default.
- W2071305174 creator A5044223656 @default.
- W2071305174 creator A5046722857 @default.
- W2071305174 creator A5053638991 @default.
- W2071305174 creator A5064038484 @default.
- W2071305174 creator A5067955744 @default.
- W2071305174 date "2000-03-01" @default.
- W2071305174 modified "2023-10-01" @default.
- W2071305174 title "Species differences in peroxisome proliferation; mechanisms and relevance" @default.
- W2071305174 cites W109571677 @default.
- W2071305174 cites W1554504884 @default.
- W2071305174 cites W1567127662 @default.
- W2071305174 cites W1643947316 @default.
- W2071305174 cites W1671834350 @default.
- W2071305174 cites W1737329440 @default.
- W2071305174 cites W178649100 @default.
- W2071305174 cites W1798702976 @default.
- W2071305174 cites W1847827438 @default.
- W2071305174 cites W1963874292 @default.
- W2071305174 cites W1970558815 @default.
- W2071305174 cites W1975640718 @default.
- W2071305174 cites W1976976178 @default.
- W2071305174 cites W1978125779 @default.
- W2071305174 cites W1985400591 @default.
- W2071305174 cites W1985898565 @default.
- W2071305174 cites W1989321849 @default.
- W2071305174 cites W1990363890 @default.
- W2071305174 cites W1990393400 @default.
- W2071305174 cites W1996520281 @default.
- W2071305174 cites W1998280047 @default.
- W2071305174 cites W1998699321 @default.
- W2071305174 cites W2002779922 @default.
- W2071305174 cites W2003881043 @default.
- W2071305174 cites W2003960793 @default.
- W2071305174 cites W2019899393 @default.
- W2071305174 cites W2021795224 @default.
- W2071305174 cites W2024341709 @default.
- W2071305174 cites W2031633834 @default.
- W2071305174 cites W2038687512 @default.
- W2071305174 cites W2039423436 @default.
- W2071305174 cites W2045984034 @default.
- W2071305174 cites W2048133075 @default.
- W2071305174 cites W2048869216 @default.
- W2071305174 cites W2053911293 @default.
- W2071305174 cites W2063559349 @default.
- W2071305174 cites W2066092624 @default.
- W2071305174 cites W2068466156 @default.
- W2071305174 cites W2068669347 @default.
- W2071305174 cites W2073497058 @default.
- W2071305174 cites W2074058488 @default.
- W2071305174 cites W2080721799 @default.
- W2071305174 cites W2081422436 @default.
- W2071305174 cites W2087936004 @default.
- W2071305174 cites W2088986997 @default.
- W2071305174 cites W2097382368 @default.
- W2071305174 cites W2102941368 @default.
- W2071305174 cites W2112709904 @default.
- W2071305174 cites W2118423087 @default.
- W2071305174 cites W2119016586 @default.
- W2071305174 cites W2120865762 @default.
- W2071305174 cites W2121914083 @default.
- W2071305174 cites W2131037449 @default.
- W2071305174 cites W2139692118 @default.
- W2071305174 cites W2149503684 @default.
- W2071305174 cites W2153071843 @default.
- W2071305174 cites W2153192590 @default.
- W2071305174 cites W2161466324 @default.
- W2071305174 cites W2168300082 @default.
- W2071305174 cites W2171119762 @default.
- W2071305174 cites W2184790393 @default.
- W2071305174 cites W2188031941 @default.
- W2071305174 cites W2323717886 @default.
- W2071305174 cites W2344151999 @default.
- W2071305174 cites W2400814031 @default.
- W2071305174 cites W2414330523 @default.
- W2071305174 cites W4252969106 @default.
- W2071305174 cites W4291113916 @default.
- W2071305174 doi "https://doi.org/10.1016/s0027-5107(99)00237-7" @default.
- W2071305174 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10725473" @default.
- W2071305174 hasPublicationYear "2000" @default.
- W2071305174 type Work @default.
- W2071305174 sameAs 2071305174 @default.
- W2071305174 citedByCount "48" @default.
- W2071305174 countsByYear W20713051742012 @default.
- W2071305174 countsByYear W20713051742013 @default.
- W2071305174 countsByYear W20713051742014 @default.
- W2071305174 countsByYear W20713051742015 @default.
- W2071305174 countsByYear W20713051742016 @default.
- W2071305174 countsByYear W20713051742017 @default.
- W2071305174 countsByYear W20713051742022 @default.
- W2071305174 crossrefType "journal-article" @default.
- W2071305174 hasAuthorship W2071305174A5028138093 @default.
- W2071305174 hasAuthorship W2071305174A5043334356 @default.
- W2071305174 hasAuthorship W2071305174A5044223656 @default.
- W2071305174 hasAuthorship W2071305174A5046722857 @default.