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• W2071305557 abstract "Shared derived genomic characters can be useful for polarizing phylogenetic relationships, for example, gene fusions have been used to identify deep-branching relationships in the eukaryotes. Here, we report the evolutionary analysis of a three-gene fusion of folB, folK, and folP, which encode enzymes that catalyze consecutive steps in de novo folate biosynthesis. The folK-folP fusion was found across the eukaryotes and a sparse collection of prokaryotes. This suggests an ancient derivation with a number of gene losses in the eukaryotes potentially as a consequence of adaptation to heterotrophic lifestyles. In contrast, the folB-folK-folP gene is specific to a mosaic collection of Amorphea taxa (a group encompassing: Amoebozoa, Apusomonadida, Breviatea, and Opisthokonta). Next, we investigated the stability of this character. We identified numerous gene losses and a total of nine gene fission events, either by break up of an open reading frame (four events identified) or loss of a component domain (five events identified). This indicates that this three gene fusion is highly labile. These data are consistent with a growing body of data indicating gene fission events occur at high relative rates. Accounting for these sources of homoplasy, our data suggest that the folB-folK-folP gene fusion was present in the last common ancestor of Amoebozoa and Opisthokonta but absent in the Metazoa including the human genome. Comparative genomic data of these genes provides an important resource for designing therapeutic strategies targeting the de novo folate biosynthesis pathway of a variety of eukaryotic pathogens such as Acanthamoeba castellanii." @default.
• W2071305557 created "2016-06-24" @default.
• W2071305557 creator A5005492049 @default.
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• W2071305557 creator A5051594885 @default.
• W2071305557 creator A5055103171 @default.
• W2071305557 creator A5074197104 @default.
• W2071305557 date "2014-09-23" @default.
• W2071305557 modified "2023-09-27" @default.
• W2071305557 title "Complex Patterns of Gene Fission in the Eukaryotic Folate Biosynthesis Pathway" @default.
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• W2071305557 doi "https://doi.org/10.1093/gbe/evu213" @default.
• W2071305557 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4224340" @default.
• W2071305557 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25252772" @default.
• W2071305557 hasPublicationYear "2014" @default.
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