Matches in SemOpenAlex for { <https://semopenalex.org/work/W2071305783> ?p ?o ?g. }
- W2071305783 endingPage "744" @default.
- W2071305783 startingPage "735" @default.
- W2071305783 abstract "Background & Aims: This randomized controlled trial compared variceal band ligation (VBL), propranolol (PPL), and isosorbide-5-mononitrate (ISMN) in the prevention of first esophageal variceal bleed. Methods: Over a 6-year period, 172 patients with cirrhosis, grade II or III esophageal varices that had never bled, were recruited; 44 into VBL, 66 into PPL, and 62 into ISMN. Baseline patient characteristics: age, 55 ± 11 years; Child–Pugh score, 8 ± 2; 65% alcohol-induced cirrhosis; follow-up period, 19.7 ± 17.6 months (range, 0.13–72.1 months), were comparable in the 3 groups. Results: On intention-to-treat analysis, variceal bleeding occurred in 7% of patients randomized to VBL, 14% to PPL, and 23% to ISMN. The 2-year actuarial risks for first variceal bleed were 6.2% (95% confidence interval [CI], 0.0%–15.0%) for VBL, 19.4% (95% CI, 0.1%–32.4%) for PPL, and 27.7% (95% CI, 14.2%–41.2%) for ISMN. A significant number of patients reported side effects with drug treatment (45% PPL and 42% ISMN vs. 2% VBL; P = 0.00), resulting in withdrawal from treatment in 30% of PPL and 21% of ISMN patients. There were no statistically significant differences in mortality rates in the 3 groups. In as-treated analysis, there was a statistically significant difference in actuarial risk for bleeding at 2 years between VBL and ISMN (7.5%, 95% CI, 2.5%–10.6% vs. 33.0%, 95% CI, 15%–49%, respectively, log rank test P = 0.03) but not between VBL and PPL. Conclusions: VBL was equivalent to PPL and superior to ISMN in preventing first variceal bleed. The side-effect profile for pharmacotherapy was considerable.GASTROENTEROLOGY 2002;123:735-744" @default.
- W2071305783 created "2016-06-24" @default.
- W2071305783 creator A5021474507 @default.
- W2071305783 creator A5032253384 @default.
- W2071305783 creator A5038955746 @default.
- W2071305783 creator A5039592976 @default.
- W2071305783 creator A5041959522 @default.
- W2071305783 creator A5044345216 @default.
- W2071305783 creator A5047324691 @default.
- W2071305783 creator A5051926617 @default.
- W2071305783 creator A5068122614 @default.
- W2071305783 date "2002-09-01" @default.
- W2071305783 modified "2023-10-16" @default.
- W2071305783 title "Primary prophylaxis of variceal hemorrhage: A randomized controlled trial comparing band ligation, propranolol, and isosorbide mononitrate" @default.
- W2071305783 cites W1582378906 @default.
- W2071305783 cites W184308473 @default.
- W2071305783 cites W1968239929 @default.
- W2071305783 cites W1984942504 @default.
- W2071305783 cites W1994397083 @default.
- W2071305783 cites W1995665201 @default.
- W2071305783 cites W1995932670 @default.
- W2071305783 cites W1996152976 @default.
- W2071305783 cites W1996738978 @default.
- W2071305783 cites W2000285716 @default.
- W2071305783 cites W2016627047 @default.
- W2071305783 cites W2032323546 @default.
- W2071305783 cites W2033314054 @default.
- W2071305783 cites W2033764809 @default.
- W2071305783 cites W2041615156 @default.
- W2071305783 cites W2044457468 @default.
- W2071305783 cites W2066963931 @default.
- W2071305783 cites W2087753422 @default.
- W2071305783 cites W2091806278 @default.
- W2071305783 cites W2100193764 @default.
- W2071305783 cites W2117898449 @default.
- W2071305783 cites W2134856258 @default.
- W2071305783 cites W2163053964 @default.
- W2071305783 cites W2164401250 @default.
- W2071305783 cites W2328498131 @default.
- W2071305783 cites W2330258550 @default.
- W2071305783 cites W2331382161 @default.
- W2071305783 cites W2795638792 @default.
- W2071305783 cites W4235137679 @default.
- W2071305783 cites W4254703726 @default.
- W2071305783 cites W4300112778 @default.
- W2071305783 doi "https://doi.org/10.1053/gast.2002.35385" @default.
- W2071305783 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12198700" @default.
- W2071305783 hasPublicationYear "2002" @default.
- W2071305783 type Work @default.
- W2071305783 sameAs 2071305783 @default.
- W2071305783 citedByCount "164" @default.
- W2071305783 countsByYear W20713057832012 @default.
- W2071305783 countsByYear W20713057832013 @default.
- W2071305783 countsByYear W20713057832014 @default.
- W2071305783 countsByYear W20713057832015 @default.
- W2071305783 countsByYear W20713057832017 @default.
- W2071305783 countsByYear W20713057832018 @default.
- W2071305783 countsByYear W20713057832019 @default.
- W2071305783 countsByYear W20713057832020 @default.
- W2071305783 countsByYear W20713057832021 @default.
- W2071305783 crossrefType "journal-article" @default.
- W2071305783 hasAuthorship W2071305783A5021474507 @default.
- W2071305783 hasAuthorship W2071305783A5032253384 @default.
- W2071305783 hasAuthorship W2071305783A5038955746 @default.
- W2071305783 hasAuthorship W2071305783A5039592976 @default.
- W2071305783 hasAuthorship W2071305783A5041959522 @default.
- W2071305783 hasAuthorship W2071305783A5044345216 @default.
- W2071305783 hasAuthorship W2071305783A5047324691 @default.
- W2071305783 hasAuthorship W2071305783A5051926617 @default.
- W2071305783 hasAuthorship W2071305783A5068122614 @default.
- W2071305783 hasConcept C126322002 @default.
- W2071305783 hasConcept C141071460 @default.
- W2071305783 hasConcept C168563851 @default.
- W2071305783 hasConcept C2776259030 @default.
- W2071305783 hasConcept C2777214474 @default.
- W2071305783 hasConcept C2777595160 @default.
- W2071305783 hasConcept C2778012290 @default.
- W2071305783 hasConcept C2778492647 @default.
- W2071305783 hasConcept C2778808290 @default.
- W2071305783 hasConcept C44249647 @default.
- W2071305783 hasConcept C71924100 @default.
- W2071305783 hasConcept C90924648 @default.
- W2071305783 hasConceptScore W2071305783C126322002 @default.
- W2071305783 hasConceptScore W2071305783C141071460 @default.
- W2071305783 hasConceptScore W2071305783C168563851 @default.
- W2071305783 hasConceptScore W2071305783C2776259030 @default.
- W2071305783 hasConceptScore W2071305783C2777214474 @default.
- W2071305783 hasConceptScore W2071305783C2777595160 @default.
- W2071305783 hasConceptScore W2071305783C2778012290 @default.
- W2071305783 hasConceptScore W2071305783C2778492647 @default.
- W2071305783 hasConceptScore W2071305783C2778808290 @default.
- W2071305783 hasConceptScore W2071305783C44249647 @default.
- W2071305783 hasConceptScore W2071305783C71924100 @default.
- W2071305783 hasConceptScore W2071305783C90924648 @default.
- W2071305783 hasIssue "3" @default.
- W2071305783 hasLocation W20713057831 @default.
- W2071305783 hasLocation W20713057832 @default.
- W2071305783 hasOpenAccess W2071305783 @default.