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- W2071305888 startingPage "1072" @default.
- W2071305888 abstract "Abstract Although phosphatases are key players of intracellular processes, not much is known about the phosphatase SHP‐2 during T cell differentiation. Here we show that ectopic over‐expression of SHP‐2 in primary T helper cells directly reduced the frequency of individual lymphocytes expressing pro‐inflammatory cytokines after antigen‐specific stimulation by a mechanism impairing activation of protein kinase C. In addition we demonstrate that SHP‐2 mediates enhanced migration upon CXCR4 signaling in a G‐protein‐dependent manner. Most strikingly, SHP‐2 mediated a dramatic increase in apoptosis by highly enhanced activation of caspases. Co‐immunoprecipitations of SHP‐2 and c‐Cbl from primary T helper cells demonstrated that SHP‐2 strongly interacts with the ubiquitin ligase c‐Cbl, indicating that c‐Cbl could mediate the negative signals of SHP‐2. Our results show that SHP‐2 signal transduction regulates central checkpoints of T cell differentiation by the activation of distinct signaling cascades." @default.
- W2071305888 created "2016-06-24" @default.
- W2071305888 creator A5034734789 @default.
- W2071305888 creator A5046891162 @default.
- W2071305888 date "2007-03-28" @default.
- W2071305888 modified "2023-10-18" @default.
- W2071305888 title "The tyrosine phosphatase SHP-2 regulates differentiation and apoptosis of individual primary T lymphocytes" @default.
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- W2071305888 doi "https://doi.org/10.1002/eji.200636240" @default.
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