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- W2071306510 abstract "Background: In the presence of a compatible clinical picture, the diagnosis of sarcoidosis requires pathologic confirmation of non-caseating epithelioid granuloma in affected tissues. The standard procedure of choice for most patients is bronchoscopy with transbronchial biopsy (TBB), which has a diagnostic yield ranging from 40-90%. The lowest yield with TBB is encountered in cases with predominant mediastinal or intraabdominal lymphadenopathy (LN) and minimal parenchymal lung involvement. In these settings, endoscopic ultrasound (EUS) guided fine needle aspiration (FNA) may provide an alternative diagnostic modality. Methods: Retrospective analysis of 21 patients (10 male and 11 female) with clinical suspicion of sarcoidosis and mediastinal and/or intraabdominal LN or masses on CT who underwent EUS-guided FNA. Results: EUS-guided FNA diagnosed sarcoidosis in 18 out of 21 (86%) patients. In three patient EUS-guided FNA was inconclusive and patients underwent mediastinoscopy with lymphadenectomy which established the diagnosis of sarcoidosis. Five of the 21 patients had intraabdominal LN/masses, and EUS-guided FNA of the intraabdominal pathology was diagnostic of sarcoidosis in three out the five patients (60%). One of the five patients was diagnosed via EUS-guided FNA of mediastinal LN and the other patient via mediastinoscopy. Three of the 21 patients had prior history of malignancy and EUS-guided FNA had ruled out the recurrence of malignancy in this subset of patients. Conclusion: EUS-guided FNA offers a practical, minimally invasive technique for the diagnosis of sarcoidosis in patients presenting with predominant mediastinal or intraabdominal LN or masses." @default.
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- W2071306510 date "2006-04-01" @default.
- W2071306510 modified "2023-10-12" @default.
- W2071306510 title "Diagnosis of Intraabdominal and Mediastinal Sarcoidosis Using Endoscopic Ultrasound Guided Fine Needle Aspiration" @default.
- W2071306510 doi "https://doi.org/10.1016/j.gie.2006.03.685" @default.
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