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- W2071306899 abstract "The metabolism of calcium and phosphate with references to blood cells was studied in five preterm infants with RDS. The times of the sampling were in the first 12hrs, on the 3rd day of oxygen (O2) therapy and 24hrs after the discontinuation of O2. The results were compared with those of matching controls. SeCa started low (7.59±0.4 mg/dl) as in controls (7.61±0.33 mg/dl) and rose steadily to reach higher levels in the third sample (10.86±0.45 against 9.55±0.22 mg/dl). The preterm babies were on IV Ca-gluconate during O2 therapy. Inorganic phosphate (Pi) in plasma was low (4.03±0.37 against 5.4±0.32 mg/dl) and continued falling till the end of the study to 2.83±0.3 compared to 6±0.03 mg/dl of the corresponding controls. In red cells Pi started normal (2.68±0.34 mg/dl) but fell all through to 1.07±0.37 compared to 3.12±0.32 mg/dl of the controls. Red cell ATP and 2, 3DPG were found low at start (1.22±0.17 and 3.88±0.61mmol/l respectively) and did not improve with the administration of O2. In conclusion RDS leads to disturbances in Pi metabolism which persist even after the subsiding of the disease and the end of O2 therapy. The IV administration of phosphate might have a beneficial effect on these neonates specially during the acute stage of RDS. However further work is needed to investigate the time course and the extend of these disturbances." @default.
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- W2071306899 date "1986-11-01" @default.
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- W2071306899 title "PHOSPHATE METABOLISM IN RESPIRATORY DISTRESS SYNDROME (RDS)" @default.
- W2071306899 doi "https://doi.org/10.1203/00006450-198611000-00206" @default.
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