FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2071307574> ?p ?o ?g. }

• W2071307574 endingPage "668" @default.
• W2071307574 startingPage "661" @default.
• W2071307574 abstract "EBV-encoded LMP-1 is absolutely required for EBV transformation of cells. Previous studies showed that LMP-1 is responsible for mediating resistance to the anti-proliferative effects of TGF-beta that characterizes EBV-transformed cells. To clarify the mechanisms of resistance to TGF-beta by LMP-1, we examined the effect of expression of LMP-1 on the activity of TGF-beta-responsive promoters. Interestingly, LMP-1 inhibited TGF-beta-responsive promoters activity despite lack of direct interaction of LMP-1 and Smad proteins, intracellular signaling molecules in the TGF-beta signal transduction pathway. Although TGF-beta treatment increased the expression of p15, TGF-beta-induced gene, this effect was counteracted by expression of LMP-1. The repressive effect was mapped to the NF-kappaB activation domains in the cytoplasmic carboxyl terminus of LMP-1. Furthermore, LMP-1-mediated inhibition of TGF-beta-responsive promoter was markedly restored after inhibition of NF-kappaB activity. LMP-1 failed to affect receptor-dependent formation of heteromers containing Smad proteins as well as the DNA-binding activity of Smad proteins. Overexpression of the transcriptional coactivator CBP and p300 abrogated the inhibitory effect of LMP-1 on the TGF-beta-responsive promoter. Our results suggest that LMP-1 represses the TGF-beta signaling through the NF-kappaB signaling pathway at transcriptional level by competing for a limited pool of transcriptional coactivators. These results enhance our understanding of the molecular mechanisms of viral pathogenesis in EBV-associated malignancies." @default.
• W2071307574 created "2016-06-24" @default.
• W2071307574 creator A5000823812 @default.
• W2071307574 creator A5006845416 @default.
• W2071307574 creator A5051242188 @default.
• W2071307574 creator A5078666381 @default.
• W2071307574 date "2003-05-05" @default.
• W2071307574 modified "2023-10-13" @default.
• W2071307574 title "Repression of Smad-dependent transforming growth factor-? signaling by Epstein-Barr virus latent membrane protein 1 through nuclear factor-?B" @default.
• W2071307574 cites W1491749295 @default.
• W2071307574 cites W1494055834 @default.
• W2071307574 cites W1497005060 @default.
• W2071307574 cites W1507472194 @default.
• W2071307574 cites W1515719112 @default.
• W2071307574 cites W1532921008 @default.
• W2071307574 cites W1913508491 @default.
• W2071307574 cites W1915074145 @default.
• W2071307574 cites W1966687443 @default.
• W2071307574 cites W1969683835 @default.
• W2071307574 cites W1971846249 @default.
• W2071307574 cites W1972992388 @default.
• W2071307574 cites W1979195453 @default.
• W2071307574 cites W1982884899 @default.
• W2071307574 cites W1993308590 @default.
• W2071307574 cites W2018465340 @default.
• W2071307574 cites W2020166689 @default.
• W2071307574 cites W2026436579 @default.
• W2071307574 cites W2029827117 @default.
• W2071307574 cites W2052096221 @default.
• W2071307574 cites W2065187149 @default.
• W2071307574 cites W2070470162 @default.
• W2071307574 cites W2074167709 @default.
• W2071307574 cites W2088549259 @default.
• W2071307574 cites W2089651572 @default.
• W2071307574 cites W2094799975 @default.
• W2071307574 cites W2103914249 @default.
• W2071307574 cites W2106877484 @default.
• W2071307574 cites W2119727612 @default.
• W2071307574 cites W2123898551 @default.
• W2071307574 cites W2133516143 @default.
• W2071307574 cites W2134542375 @default.
• W2071307574 cites W2164615751 @default.
• W2071307574 cites W2166380829 @default.
• W2071307574 cites W2327138509 @default.
• W2071307574 cites W2401052641 @default.
• W2071307574 cites W4296927411 @default.
• W2071307574 doi "https://doi.org/10.1002/ijc.11146" @default.
• W2071307574 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12740915" @default.
• W2071307574 hasPublicationYear "2003" @default.
• W2071307574 type Work @default.
• W2071307574 sameAs 2071307574 @default.
• W2071307574 citedByCount "32" @default.
• W2071307574 countsByYear W20713075742012 @default.
• W2071307574 countsByYear W20713075742013 @default.
• W2071307574 countsByYear W20713075742016 @default.
• W2071307574 countsByYear W20713075742018 @default.
• W2071307574 countsByYear W20713075742020 @default.
• W2071307574 countsByYear W20713075742021 @default.
• W2071307574 crossrefType "journal-article" @default.
• W2071307574 hasAuthorship W2071307574A5000823812 @default.
• W2071307574 hasAuthorship W2071307574A5006845416 @default.
• W2071307574 hasAuthorship W2071307574A5051242188 @default.
• W2071307574 hasAuthorship W2071307574A5078666381 @default.
• W2071307574 hasBestOaLocation W20713075741 @default.
• W2071307574 hasConcept C104317684 @default.
• W2071307574 hasConcept C125555471 @default.
• W2071307574 hasConcept C153911025 @default.
• W2071307574 hasConcept C165864922 @default.
• W2071307574 hasConcept C170493617 @default.
• W2071307574 hasConcept C2775960820 @default.
• W2071307574 hasConcept C2778229498 @default.
• W2071307574 hasConcept C2781080636 @default.
• W2071307574 hasConcept C54355233 @default.
• W2071307574 hasConcept C62478195 @default.
• W2071307574 hasConcept C73568257 @default.
• W2071307574 hasConcept C77445288 @default.
• W2071307574 hasConcept C86339819 @default.
• W2071307574 hasConcept C86803240 @default.
• W2071307574 hasConcept C95444343 @default.
• W2071307574 hasConceptScore W2071307574C104317684 @default.
• W2071307574 hasConceptScore W2071307574C125555471 @default.
• W2071307574 hasConceptScore W2071307574C153911025 @default.
• W2071307574 hasConceptScore W2071307574C165864922 @default.
• W2071307574 hasConceptScore W2071307574C170493617 @default.
• W2071307574 hasConceptScore W2071307574C2775960820 @default.
• W2071307574 hasConceptScore W2071307574C2778229498 @default.
• W2071307574 hasConceptScore W2071307574C2781080636 @default.
• W2071307574 hasConceptScore W2071307574C54355233 @default.
• W2071307574 hasConceptScore W2071307574C62478195 @default.
• W2071307574 hasConceptScore W2071307574C73568257 @default.
• W2071307574 hasConceptScore W2071307574C77445288 @default.
• W2071307574 hasConceptScore W2071307574C86339819 @default.
• W2071307574 hasConceptScore W2071307574C86803240 @default.
• W2071307574 hasConceptScore W2071307574C95444343 @default.
• W2071307574 hasIssue "5" @default.
• W2071307574 hasLocation W20713075741 @default.
• W2071307574 hasLocation W20713075742 @default.
• W2071307574 hasOpenAccess W2071307574 @default.

• next