FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2071309426> ?p ?o ?g. }

• W2071309426 endingPage "431" @default.
• W2071309426 startingPage "423" @default.
• W2071309426 abstract "Because evasion of tumor suppression is a critical step in cancer development, cancer cells have developed a variety of mechanisms to circumvent the influence of tumor suppressive pathways. Thus, genes that negatively regulate tumor suppressors could be considered novel types of oncogenes such as Bmi-1 repressing p16Ink4a and inhibiting p53 and were found to be frequently up-regulated in a variety of cancers. p38 mitogen-activated protein kinase (MAPK), which reportedly plays a crucial role as a tumor suppressor, is activated in number of lung adenocarcinomas, which is seemingly at odds with its role as a tumor suppressor.We examined 10 lung adenocarcinomas and corresponding normal tissues and determined the expression levels of a variety of tumor suppressor proteins through real-time polymerase chain reaction and immunohistochemistry and measured p38 MAPK activity by immunoblotting or immunohistochemistry analysis. In the in vitro cellular model, p38 activation by H-Ras and consequent senescence induction was achieved through retro-viral gene transduction. Similarly, the suppression of p16Ink4a by Bmi-1 after the introduction of H-Ras was achieved through transient transfection with cationic liposome.We detected several lung adenocarcinomas that were positive for activated p38 MAPK but evidenced reduced levels of p16Ink4a expression. The suppression of p16Ink4a occurred in parallel with an increase in Bmi-1 and/or p16Ink4a promoter hypermethylation. Consistent with these observations, the H-Ras-stimulated induction of p16Ink4a was suppressed significantly through the coexpression of Bmi-1 in vitro.These results demonstrate that the suppression of p16Ink4a by either the induction of Bmi-1 or the hypermethylation of p16Ink4 may be an important step in avoiding tumor surveillance by p38 MAPK during the development of lung cancer." @default.
• W2071309426 created "2016-06-24" @default.
• W2071309426 creator A5017562183 @default.
• W2071309426 creator A5018022855 @default.
• W2071309426 creator A5020752812 @default.
• W2071309426 creator A5027381296 @default.
• W2071309426 creator A5035796008 @default.
• W2071309426 creator A5052840748 @default.
• W2071309426 creator A5059501045 @default.
• W2071309426 creator A5067651226 @default.
• W2071309426 creator A5069376606 @default.
• W2071309426 creator A5079477825 @default.
• W2071309426 creator A5082152746 @default.
• W2071309426 date "2011-03-01" @default.
• W2071309426 modified "2023-10-14" @default.
• W2071309426 title "p16Ink4a Suppression of Lung Adenocarcinoma by Bmi-1 in the Presence of p38 Activation" @default.
• W2071309426 cites W1481473039 @default.
• W2071309426 cites W1566737177 @default.
• W2071309426 cites W1973009553 @default.
• W2071309426 cites W1974496908 @default.
• W2071309426 cites W1976462601 @default.
• W2071309426 cites W1978120498 @default.
• W2071309426 cites W1983979356 @default.
• W2071309426 cites W1986594019 @default.
• W2071309426 cites W1987196013 @default.
• W2071309426 cites W1994465394 @default.
• W2071309426 cites W1999207367 @default.
• W2071309426 cites W1999460438 @default.
• W2071309426 cites W2004567377 @default.
• W2071309426 cites W2015183783 @default.
• W2071309426 cites W2016149929 @default.
• W2071309426 cites W2019047723 @default.
• W2071309426 cites W2022557585 @default.
• W2071309426 cites W2034269086 @default.
• W2071309426 cites W2039030772 @default.
• W2071309426 cites W2043001725 @default.
• W2071309426 cites W2043027414 @default.
• W2071309426 cites W2043103956 @default.
• W2071309426 cites W2049085719 @default.
• W2071309426 cites W2052787443 @default.
• W2071309426 cites W2058830224 @default.
• W2071309426 cites W2074364031 @default.
• W2071309426 cites W2076234267 @default.
• W2071309426 cites W2081113836 @default.
• W2071309426 cites W2083247246 @default.
• W2071309426 cites W2084296544 @default.
• W2071309426 cites W2087404852 @default.
• W2071309426 cites W2088308108 @default.
• W2071309426 cites W2089896836 @default.
• W2071309426 cites W2110511887 @default.
• W2071309426 cites W2112849045 @default.
• W2071309426 cites W2122293957 @default.
• W2071309426 cites W2125003296 @default.
• W2071309426 cites W2125547572 @default.
• W2071309426 cites W2132244436 @default.
• W2071309426 cites W2150583263 @default.
• W2071309426 cites W2168395104 @default.
• W2071309426 cites W2172101615 @default.
• W2071309426 cites W2329587797 @default.
• W2071309426 cites W2566863750 @default.
• W2071309426 cites W31151557 @default.
• W2071309426 cites W2064166219 @default.
• W2071309426 doi "https://doi.org/10.1097/jto.0b013e3182018ace" @default.
• W2071309426 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21164364" @default.
• W2071309426 hasPublicationYear "2011" @default.
• W2071309426 type Work @default.
• W2071309426 sameAs 2071309426 @default.
• W2071309426 citedByCount "9" @default.
• W2071309426 countsByYear W20713094262012 @default.
• W2071309426 countsByYear W20713094262014 @default.
• W2071309426 countsByYear W20713094262015 @default.
• W2071309426 countsByYear W20713094262016 @default.
• W2071309426 countsByYear W20713094262017 @default.
• W2071309426 crossrefType "journal-article" @default.
• W2071309426 hasAuthorship W2071309426A5017562183 @default.
• W2071309426 hasAuthorship W2071309426A5018022855 @default.
• W2071309426 hasAuthorship W2071309426A5020752812 @default.
• W2071309426 hasAuthorship W2071309426A5027381296 @default.
• W2071309426 hasAuthorship W2071309426A5035796008 @default.
• W2071309426 hasAuthorship W2071309426A5052840748 @default.
• W2071309426 hasAuthorship W2071309426A5059501045 @default.
• W2071309426 hasAuthorship W2071309426A5067651226 @default.
• W2071309426 hasAuthorship W2071309426A5069376606 @default.
• W2071309426 hasAuthorship W2071309426A5079477825 @default.
• W2071309426 hasAuthorship W2071309426A5082152746 @default.
• W2071309426 hasBestOaLocation W20713094261 @default.
• W2071309426 hasConcept C104317684 @default.
• W2071309426 hasConcept C121608353 @default.
• W2071309426 hasConcept C126322002 @default.
• W2071309426 hasConcept C179185449 @default.
• W2071309426 hasConcept C184235292 @default.
• W2071309426 hasConcept C204232928 @default.
• W2071309426 hasConcept C2776256026 @default.
• W2071309426 hasConcept C2778264664 @default.
• W2071309426 hasConcept C2781182431 @default.
• W2071309426 hasConcept C502942594 @default.
• W2071309426 hasConcept C51551487 @default.
• W2071309426 hasConcept C54009773 @default.

• next