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- W2071320186 abstract "The effect of insulin-induced hypoglycemia on spontaneous peripheral neuropathy in aged mice was examined. Ninety-five-week-old female B6C3F1 mice were infused subcutaneously for 2 weeks with 40 or 80 IU/kg/day of insulin with a micro osmotic pump. Blood glucose level was decreased during the infusion (4.3-6.8 mmol/L in mice receiving 40 IU/kg/day of insulin or 2.4-5.4 mmol/L in mice receiving 80 IU/kg/day of insulin versus 6.5-7.6 mmol/L in control mice). In histopathological examination, axonal degeneration and/or remyelination were observed in a small number of nerve fibers of control mice. Similar nerve fiber lesions were observed in mice receiving 40 IU/kg/day of insulin, whereas severer lesions with an increase in segmental axonal degeneration of nerve fibers were observed in 4/7 mice receiving 80 IU/kg/day of insulin. These findings suggest that spontaneous peripheral neuropathy in aged mice is exacerbated by sustained hypoglycemia induced by insulin treatment." @default.
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- W2071320186 title "The exacerbating effect of insulin-induced hypoglycemia on spontaneous peripheral neuropathy in aged B6C3F1 mice." @default.
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- W2071320186 doi "https://doi.org/10.2131/jts.25.137" @default.
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