Matches in SemOpenAlex for { <https://semopenalex.org/work/W2071330016> ?p ?o ?g. }
Showing items 1 to 82 of
82
with 100 items per page.
- W2071330016 endingPage "417" @default.
- W2071330016 startingPage "411" @default.
- W2071330016 abstract "A high-performance liquid chromatographic method has been developed for the simultaneous determination of metoprolol and its α-hydroxylated metabolite in plasma, Metoprolol, α-hydroxymetoprolol and alprenolol (internal standard) are extracted from plasma at alkaline pH with diethyl ether—dichloromethane (4:1, v/v) and back-extracted with 0.01 N sulfuric acid. A 100-μl volume of the acidic extract is injected into the chromatographic system. The compounds are eluted in about 12 min with acetonitrile—acetate buffer (75:25, v/v) on a LiChrosorb RP-8 (5 μm) column. The quantitative determinations are made fluorometrically. Concentrations down to 35 nmol/l (10 ng/ml) of metoprolol base and 30 nmol/l (8 ng/ml) of α-hydroxymetoprolol base in plasma can be determined with good precision and accuracy." @default.
- W2071330016 created "2016-06-24" @default.
- W2071330016 creator A5011660046 @default.
- W2071330016 creator A5041845907 @default.
- W2071330016 creator A5087409115 @default.
- W2071330016 creator A5088211107 @default.
- W2071330016 date "1984-01-01" @default.
- W2071330016 modified "2023-09-26" @default.
- W2071330016 title "Determination of metoprolol and its α-hydroxylated metabolite in human plasma by high-performance liquid chromatography" @default.
- W2071330016 cites W1980322268 @default.
- W2071330016 cites W1990608011 @default.
- W2071330016 cites W1992143405 @default.
- W2071330016 cites W2001076482 @default.
- W2071330016 cites W2020297004 @default.
- W2071330016 cites W2042101335 @default.
- W2071330016 cites W2061601482 @default.
- W2071330016 cites W2087500584 @default.
- W2071330016 cites W2148747057 @default.
- W2071330016 cites W2883030338 @default.
- W2071330016 doi "https://doi.org/10.1016/s0378-4347(00)83355-1" @default.
- W2071330016 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6707168" @default.
- W2071330016 hasPublicationYear "1984" @default.
- W2071330016 type Work @default.
- W2071330016 sameAs 2071330016 @default.
- W2071330016 citedByCount "22" @default.
- W2071330016 countsByYear W20713300162012 @default.
- W2071330016 crossrefType "journal-article" @default.
- W2071330016 hasAuthorship W2071330016A5011660046 @default.
- W2071330016 hasAuthorship W2071330016A5041845907 @default.
- W2071330016 hasAuthorship W2071330016A5087409115 @default.
- W2071330016 hasAuthorship W2071330016A5088211107 @default.
- W2071330016 hasConcept C164705383 @default.
- W2071330016 hasConcept C178790620 @default.
- W2071330016 hasConcept C179998833 @default.
- W2071330016 hasConcept C185592680 @default.
- W2071330016 hasConcept C2776721371 @default.
- W2071330016 hasConcept C2777463227 @default.
- W2071330016 hasConcept C2777477808 @default.
- W2071330016 hasConcept C2778199549 @default.
- W2071330016 hasConcept C2780400988 @default.
- W2071330016 hasConcept C2780471494 @default.
- W2071330016 hasConcept C2781280847 @default.
- W2071330016 hasConcept C43617362 @default.
- W2071330016 hasConcept C55493867 @default.
- W2071330016 hasConcept C71924100 @default.
- W2071330016 hasConcept C73826308 @default.
- W2071330016 hasConceptScore W2071330016C164705383 @default.
- W2071330016 hasConceptScore W2071330016C178790620 @default.
- W2071330016 hasConceptScore W2071330016C179998833 @default.
- W2071330016 hasConceptScore W2071330016C185592680 @default.
- W2071330016 hasConceptScore W2071330016C2776721371 @default.
- W2071330016 hasConceptScore W2071330016C2777463227 @default.
- W2071330016 hasConceptScore W2071330016C2777477808 @default.
- W2071330016 hasConceptScore W2071330016C2778199549 @default.
- W2071330016 hasConceptScore W2071330016C2780400988 @default.
- W2071330016 hasConceptScore W2071330016C2780471494 @default.
- W2071330016 hasConceptScore W2071330016C2781280847 @default.
- W2071330016 hasConceptScore W2071330016C43617362 @default.
- W2071330016 hasConceptScore W2071330016C55493867 @default.
- W2071330016 hasConceptScore W2071330016C71924100 @default.
- W2071330016 hasConceptScore W2071330016C73826308 @default.
- W2071330016 hasLocation W20713300161 @default.
- W2071330016 hasLocation W20713300162 @default.
- W2071330016 hasOpenAccess W2071330016 @default.
- W2071330016 hasPrimaryLocation W20713300161 @default.
- W2071330016 hasRelatedWork W2010723684 @default.
- W2071330016 hasRelatedWork W2043512602 @default.
- W2071330016 hasRelatedWork W2049606890 @default.
- W2071330016 hasRelatedWork W2056980537 @default.
- W2071330016 hasRelatedWork W2079852636 @default.
- W2071330016 hasRelatedWork W2085491095 @default.
- W2071330016 hasRelatedWork W2119552130 @default.
- W2071330016 hasRelatedWork W2321445466 @default.
- W2071330016 hasRelatedWork W2385807189 @default.
- W2071330016 hasRelatedWork W66516859 @default.
- W2071330016 hasVolume "305" @default.
- W2071330016 isParatext "false" @default.
- W2071330016 isRetracted "false" @default.
- W2071330016 magId "2071330016" @default.
- W2071330016 workType "article" @default.