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• W2071330332 abstract "The exact identification of B cell subsets is instrumental to understand their dynamics under physiological and pathological conditions. Human memory B cells are currently identified according to the expression of CD27, which is absent on naive B cells. We report here that the ATP-binding cassette (ABC)B1 transporter is exclusively present on mature CD27- naive B cells, while it is absent in CD27+ memory B cells and in a heterogeneous subset of CD27- cells that comprise both switch memory and transitional B cells. Thus, ABCB1 activity precisely discriminates naive from transitional and all memory B cells. Using this improved method to discriminate human B cell subsets, and Ki67 staining to identify recently divided cells, we show that in both cord blood and adult peripheral blood, mature naive B cells are quiescent while transitional B cells and memory B cells have a high in vivo turnover." @default.
• W2071330332 created "2016-06-24" @default.
• W2071330332 creator A5031869321 @default.
• W2071330332 creator A5059965999 @default.
• W2071330332 date "2005-12-01" @default.
• W2071330332 modified "2023-10-14" @default.
• W2071330332 title "ABCB1 transporter discriminates human resting naive B cells from cycling transitional and memory B cells" @default.
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• W2071330332 doi "https://doi.org/10.1002/eji.200535364" @default.
• W2071330332 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16259010" @default.
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