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- W2071337010 endingPage "1545" @default.
- W2071337010 startingPage "1534" @default.
- W2071337010 abstract "Mitochondria typically form a reticular network radiating from the nucleus, creating an interconnected system that supplies the cell with essential energy and metabolites. These mitochondrial networks are regulated through the complex coordination of fission, fusion and distribution events. While a number of key mitochondrial morphology proteins have been identified, the precise mechanisms which govern their activity remain elusive. Moreover, post translational modifications including ubiquitination, phosphorylation and sumoylation of the core machinery are thought to regulate both fusion and division of the network. These proteins can undergo several different modifications depending on cellular signals, environment and energetic demands of the cell. Proteins involved in mitochondrial morphology may also have dual roles in both dynamics and apoptosis, with regulation of these proteins under tight control of the cell to ensure correct function. The absolute reliance of the cell on a functional mitochondrial network is highlighted in neurons, which are particularly vulnerable to any changes in organelle dynamics due to their unique biochemical requirements. Recent evidence suggests that defects in the shape or distribution of mitochondria correlate with the progression of neurodegenerative diseases such as Alzheimer's, Huntington's and Parkinson's disease. This review focuses on our current understanding of the mitochondrial morphology machinery in cell homeostasis, apoptosis and neurodegeneration, and the post translational modifications that regulate these processes." @default.
- W2071337010 created "2016-06-24" @default.
- W2071337010 creator A5042624738 @default.
- W2071337010 creator A5052343612 @default.
- W2071337010 creator A5076160885 @default.
- W2071337010 creator A5076790544 @default.
- W2071337010 date "2011-10-01" @default.
- W2071337010 modified "2023-10-14" @default.
- W2071337010 title "The regulation of mitochondrial morphology: Intricate mechanisms and dynamic machinery" @default.
- W2071337010 cites W1493752155 @default.
- W2071337010 cites W1550876205 @default.
- W2071337010 cites W1561484646 @default.
- W2071337010 cites W1564336783 @default.
- W2071337010 cites W1963715201 @default.
- W2071337010 cites W1966241472 @default.
- W2071337010 cites W1967445833 @default.
- W2071337010 cites W1970248089 @default.
- W2071337010 cites W1970826466 @default.
- W2071337010 cites W1973055895 @default.
- W2071337010 cites W1974958475 @default.
- W2071337010 cites W1976645698 @default.
- W2071337010 cites W1976779549 @default.
- W2071337010 cites W1978268445 @default.
- W2071337010 cites W1979489548 @default.
- W2071337010 cites W1980103053 @default.
- W2071337010 cites W1982176321 @default.
- W2071337010 cites W1982334342 @default.
- W2071337010 cites W1985119207 @default.
- W2071337010 cites W1986996580 @default.
- W2071337010 cites W1987459699 @default.
- W2071337010 cites W1987845572 @default.
- W2071337010 cites W1989167108 @default.
- W2071337010 cites W1989540421 @default.
- W2071337010 cites W1989554731 @default.
- W2071337010 cites W1991994507 @default.
- W2071337010 cites W1993490757 @default.
- W2071337010 cites W2000528910 @default.
- W2071337010 cites W2002321863 @default.
- W2071337010 cites W2003346050 @default.
- W2071337010 cites W2003705213 @default.
- W2071337010 cites W2003774554 @default.
- W2071337010 cites W2004939344 @default.
- W2071337010 cites W2004968462 @default.
- W2071337010 cites W2005607645 @default.
- W2071337010 cites W2005673220 @default.
- W2071337010 cites W2005764967 @default.
- W2071337010 cites W2006787533 @default.
- W2071337010 cites W2007891746 @default.
- W2071337010 cites W2007910752 @default.
- W2071337010 cites W2008560062 @default.
- W2071337010 cites W2008584420 @default.
- W2071337010 cites W2009278410 @default.
- W2071337010 cites W2014229034 @default.
- W2071337010 cites W2014777707 @default.
- W2071337010 cites W2016885670 @default.
- W2071337010 cites W2016888445 @default.
- W2071337010 cites W2017113675 @default.
- W2071337010 cites W2018019380 @default.
- W2071337010 cites W2020023492 @default.
- W2071337010 cites W2021343145 @default.
- W2071337010 cites W2022827866 @default.
- W2071337010 cites W2023283007 @default.
- W2071337010 cites W2023542615 @default.
- W2071337010 cites W2024595059 @default.
- W2071337010 cites W2024797763 @default.
- W2071337010 cites W2026912679 @default.
- W2071337010 cites W2030145039 @default.
- W2071337010 cites W2030351931 @default.
- W2071337010 cites W2032234589 @default.
- W2071337010 cites W2037024540 @default.
- W2071337010 cites W2038359917 @default.
- W2071337010 cites W2038834667 @default.
- W2071337010 cites W2039409049 @default.
- W2071337010 cites W2041001616 @default.
- W2071337010 cites W2045085957 @default.
- W2071337010 cites W2046054688 @default.
- W2071337010 cites W2048621445 @default.
- W2071337010 cites W2051698507 @default.
- W2071337010 cites W2053071718 @default.
- W2071337010 cites W2054344703 @default.
- W2071337010 cites W2055909694 @default.
- W2071337010 cites W2058645571 @default.
- W2071337010 cites W2058653820 @default.
- W2071337010 cites W2059277863 @default.
- W2071337010 cites W2059320820 @default.
- W2071337010 cites W2060811345 @default.
- W2071337010 cites W2061114093 @default.
- W2071337010 cites W2063418623 @default.
- W2071337010 cites W2064080426 @default.
- W2071337010 cites W2065018825 @default.
- W2071337010 cites W2065978277 @default.
- W2071337010 cites W2066929651 @default.
- W2071337010 cites W2067220287 @default.
- W2071337010 cites W2067299494 @default.
- W2071337010 cites W2071229320 @default.
- W2071337010 cites W2072371514 @default.
- W2071337010 cites W2073095545 @default.
- W2071337010 cites W2074189512 @default.