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- W2071342676 abstract "O N E of the important factors determining serum concentration of chloramphenicol is the rate of hepatic metabolism to inactive metabolites by the microsomal enzyme glucuronyl transferase. 1 Since both phenytoin and phenobarbital can induce hepatic microsomal enzymes, their use may increase the rate of chloramphenicol metabolism. 2 Because these drugs may be used with chloramphenicol in treating pediatric infections of the central nervous system, it is important to know how these drugs interact. We report a child with hydrocephalus who was treated with chloramphenicol for a ventriculojugular infection. Concomitant with the sequential addition of phenytoin and phenobarbital, there was a significantly lowered chloramphenicol serum concentration and an increased total body clearance of chloramphenicol relative to values reported in pediatric patients." @default.
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- W2071342676 date "1981-06-01" @default.
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- W2071342676 title "Interactions among chloramphenicol, phenytoin, and phenobarbital in a pediatric patient" @default.
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- W2071342676 doi "https://doi.org/10.1016/s0022-3476(81)80617-8" @default.
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