FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2071344265> ?p ?o ?g. }

• W2071344265 endingPage "e87915" @default.
• W2071344265 startingPage "e87915" @default.
• W2071344265 abstract "Neuroimmune gene induction is involved in many brain pathologies including addiction. Although increased expression of proinflammatory cytokines has been found in ethanol-treated mouse brain and rat brain slice cultures as well as in post-mortem human alcoholic brain, the mechanisms remain elusive. High-mobility group box 1 (HMGB1) protein is a nuclear protein that has endogenous cytokine-like activity. We previously found increased HMGB1 in post-mortem alcoholic human brain as well as in ethanol treated mice and rat brain slice cultures. The present study investigated the mechanisms for ethanol-induced release of HMGB1 and neuroimmune activation in a model of rat hippocampal-entorhinal cortex (HEC) brain slice cultures. Ethanol exposure triggered dose-dependent HMGB1 release, predominantly from neuronal cells. Inhibitors of histone deacetylases (HDACs) promoted nucleocytoplasmic mobilization of HDAC1/4 and HMGB1 resulting in increased total HMGB1 and acetylated HMGB1 release. Similarly, ethanol treatment was found to induce the translocation of HDAC1/4 and HMGB1 proteins from nuclear to cytosolic fractions. Furthermore, ethanol treatment reduced HDAC1/4 mRNA and increased acetylated HMGB1 release into the media. These results suggest decreased HDAC activity may be critical in regulating acetylated HMGB1 release from neurons in response to ethanol. Ethanol and HMGB1 treatment increased mRNA expression of proinflammatory cytokines TNFα and IL-1β as well as toll-like receptor 4 (TLR4). Targeting HMGB1 or microglial TLR4 by using siRNAs to HMGB1 and TLR4, HMGB1 neutralizing antibody, HMGB1 inhibitor glycyrrhizin and TLR4 antagonist as well as inhibitor of microglial activation all blocked ethanol-induced expression of proinflammatory cytokines TNFα and IL-1β. These results support the hypothesis that ethanol alters HDACs that regulate HMGB1 release and that danger signal HMGB1 as endogenous ligand for TLR4 mediates ethanol-induced brain neuroimmune signaling through activation of microglial TLR4. These findings provide new therapeutic targets for brain neuroimmune activation and alcoholism." @default.
• W2071344265 created "2016-06-24" @default.
• W2071344265 creator A5025097212 @default.
• W2071344265 creator A5031569610 @default.
• W2071344265 date "2014-02-14" @default.
• W2071344265 modified "2023-09-23" @default.
• W2071344265 title "Release of Neuronal HMGB1 by Ethanol through Decreased HDAC Activity Activates Brain Neuroimmune Signaling" @default.
• W2071344265 cites W1553707188 @default.
• W2071344265 cites W1560220156 @default.
• W2071344265 cites W1606879955 @default.
• W2071344265 cites W1620345881 @default.
• W2071344265 cites W1761714741 @default.
• W2071344265 cites W1902776119 @default.
• W2071344265 cites W1965942744 @default.
• W2071344265 cites W1975931952 @default.
• W2071344265 cites W1979009614 @default.
• W2071344265 cites W1986346910 @default.
• W2071344265 cites W1991538811 @default.
• W2071344265 cites W1995650166 @default.
• W2071344265 cites W2004266769 @default.
• W2071344265 cites W2009409076 @default.
• W2071344265 cites W2009962309 @default.
• W2071344265 cites W2016149358 @default.
• W2071344265 cites W2017854304 @default.
• W2071344265 cites W2018062658 @default.
• W2071344265 cites W2018653121 @default.
• W2071344265 cites W2020323703 @default.
• W2071344265 cites W2023256158 @default.
• W2071344265 cites W2023881152 @default.
• W2071344265 cites W2029068688 @default.
• W2071344265 cites W2029927321 @default.
• W2071344265 cites W2034594119 @default.
• W2071344265 cites W2055750901 @default.
• W2071344265 cites W2062312810 @default.
• W2071344265 cites W2063081068 @default.
• W2071344265 cites W2064891273 @default.
• W2071344265 cites W2068103418 @default.
• W2071344265 cites W2071260421 @default.
• W2071344265 cites W2074294483 @default.
• W2071344265 cites W2075167067 @default.
• W2071344265 cites W2079305534 @default.
• W2071344265 cites W2079489798 @default.
• W2071344265 cites W2093437371 @default.
• W2071344265 cites W2097391811 @default.
• W2071344265 cites W2103590758 @default.
• W2071344265 cites W2108163830 @default.
• W2071344265 cites W2113617025 @default.
• W2071344265 cites W2114445825 @default.
• W2071344265 cites W2116936712 @default.
• W2071344265 cites W2125365870 @default.
• W2071344265 cites W2125977732 @default.
• W2071344265 cites W2127587930 @default.
• W2071344265 cites W2134239505 @default.
• W2071344265 cites W2144679012 @default.
• W2071344265 cites W2145136979 @default.
• W2071344265 cites W2149240296 @default.
• W2071344265 cites W2170777608 @default.
• W2071344265 doi "https://doi.org/10.1371/journal.pone.0087915" @default.
• W2071344265 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3925099" @default.
• W2071344265 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24551070" @default.
• W2071344265 hasPublicationYear "2014" @default.
• W2071344265 type Work @default.
• W2071344265 sameAs 2071344265 @default.
• W2071344265 citedByCount "132" @default.
• W2071344265 countsByYear W20713442652014 @default.
• W2071344265 countsByYear W20713442652015 @default.
• W2071344265 countsByYear W20713442652016 @default.
• W2071344265 countsByYear W20713442652017 @default.
• W2071344265 countsByYear W20713442652018 @default.
• W2071344265 countsByYear W20713442652019 @default.
• W2071344265 countsByYear W20713442652020 @default.
• W2071344265 countsByYear W20713442652021 @default.
• W2071344265 countsByYear W20713442652022 @default.
• W2071344265 countsByYear W20713442652023 @default.
• W2071344265 crossrefType "journal-article" @default.
• W2071344265 hasAuthorship W2071344265A5025097212 @default.
• W2071344265 hasAuthorship W2071344265A5031569610 @default.
• W2071344265 hasBestOaLocation W20713442651 @default.
• W2071344265 hasConcept C164027704 @default.
• W2071344265 hasConcept C170493617 @default.
• W2071344265 hasConcept C185592680 @default.
• W2071344265 hasConcept C203014093 @default.
• W2071344265 hasConcept C2776070231 @default.
• W2071344265 hasConcept C2776914184 @default.
• W2071344265 hasConcept C2779830541 @default.
• W2071344265 hasConcept C2780545709 @default.
• W2071344265 hasConcept C55493867 @default.
• W2071344265 hasConcept C86803240 @default.
• W2071344265 hasConcept C87753298 @default.
• W2071344265 hasConcept C95444343 @default.
• W2071344265 hasConcept C98274493 @default.
• W2071344265 hasConceptScore W2071344265C164027704 @default.
• W2071344265 hasConceptScore W2071344265C170493617 @default.
• W2071344265 hasConceptScore W2071344265C185592680 @default.
• W2071344265 hasConceptScore W2071344265C203014093 @default.
• W2071344265 hasConceptScore W2071344265C2776070231 @default.
• W2071344265 hasConceptScore W2071344265C2776914184 @default.
• W2071344265 hasConceptScore W2071344265C2779830541 @default.

• next