Matches in SemOpenAlex for { <https://semopenalex.org/work/W2071344765> ?p ?o ?g. }
- W2071344765 endingPage "123" @default.
- W2071344765 startingPage "111" @default.
- W2071344765 abstract "Although ischemia is associated with disruption of cadherin-mediated adhesion in renal cell lines, the impact of decreased cadherin function on the transcriptional activity of beta-catenin remains poorly defined. In these studies, we used a simulated ischemia model in normal rat kidney (NRK) cells to disrupt cadherin function. Cell viability; cadherin/catenin expression, function, and localization; and beta-catenin-mediated transcriptional activity were assessed during ischemia/reperfusion. Following 6 hr of ischemia, a decrease in the expression of E- and N-cadherin was seen that correlated with altered cell morphology indicative of decreased intercellular adhesion. While ischemia was associated with activation of glycogen synthase kinase 3 beta (GSK-3beta), this did not correlate with increased phosphorylation of beta-catenin as assessed by Western blots using phosphoryl-specific antibodies. beta-Catenin was not localized to the nucleus by immunofluorescence in ischemic NRK cells, but rather a strong perinuclear signal was seen in reperfused cells. This was consistent with the finding that neither ischemia nor reperfusion activated the transcriptional activity of beta-catenin as assessed by the TCF-optimal promoter (TOPFlash) construct. However, NRK cells possess a competent Wnt pathway, as challenge with lithium chloride elicited a ten-fold increase in luciferase activity. These results suggest that ischemia-induced disruption of cadherin/catenin complexes is not sufficient to stimulate beta-catenin transcriptional activity in NRK cells." @default.
- W2071344765 created "2016-06-24" @default.
- W2071344765 creator A5016657551 @default.
- W2071344765 creator A5019067799 @default.
- W2071344765 creator A5035401835 @default.
- W2071344765 creator A5045067652 @default.
- W2071344765 creator A5056346192 @default.
- W2071344765 creator A5061582640 @default.
- W2071344765 creator A5064099505 @default.
- W2071344765 creator A5073031479 @default.
- W2071344765 date "2007-01-01" @default.
- W2071344765 modified "2023-09-26" @default.
- W2071344765 title "Ischemia-Induced Cleavage of Cadherins in NRK Cells is not Sufficient for β-catenin Transcriptional Activity" @default.
- W2071344765 cites W1925503962 @default.
- W2071344765 cites W1955427151 @default.
- W2071344765 cites W1968952664 @default.
- W2071344765 cites W1972039621 @default.
- W2071344765 cites W1975853332 @default.
- W2071344765 cites W1979970784 @default.
- W2071344765 cites W1984817163 @default.
- W2071344765 cites W1988714320 @default.
- W2071344765 cites W1990671646 @default.
- W2071344765 cites W1998316286 @default.
- W2071344765 cites W2006718453 @default.
- W2071344765 cites W2008311687 @default.
- W2071344765 cites W2012708469 @default.
- W2071344765 cites W2020709644 @default.
- W2071344765 cites W2024085078 @default.
- W2071344765 cites W2027151815 @default.
- W2071344765 cites W2031226622 @default.
- W2071344765 cites W2032621066 @default.
- W2071344765 cites W2047758846 @default.
- W2071344765 cites W2050642264 @default.
- W2071344765 cites W2056941582 @default.
- W2071344765 cites W2078981825 @default.
- W2071344765 cites W2091366275 @default.
- W2071344765 cites W2101015806 @default.
- W2071344765 cites W2102031720 @default.
- W2071344765 cites W2104523170 @default.
- W2071344765 cites W2111314225 @default.
- W2071344765 cites W2112718635 @default.
- W2071344765 cites W2118567330 @default.
- W2071344765 cites W2125904354 @default.
- W2071344765 cites W2126323165 @default.
- W2071344765 cites W2139529386 @default.
- W2071344765 cites W2145621252 @default.
- W2071344765 cites W2148294117 @default.
- W2071344765 cites W2151447394 @default.
- W2071344765 cites W2156091157 @default.
- W2071344765 cites W2158796507 @default.
- W2071344765 cites W2164218587 @default.
- W2071344765 cites W2165335202 @default.
- W2071344765 cites W2186049400 @default.
- W2071344765 cites W2187884182 @default.
- W2071344765 doi "https://doi.org/10.1080/15419060701556943" @default.
- W2071344765 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17957528" @default.
- W2071344765 hasPublicationYear "2007" @default.
- W2071344765 type Work @default.
- W2071344765 sameAs 2071344765 @default.
- W2071344765 citedByCount "4" @default.
- W2071344765 countsByYear W20713447652015 @default.
- W2071344765 crossrefType "journal-article" @default.
- W2071344765 hasAuthorship W2071344765A5016657551 @default.
- W2071344765 hasAuthorship W2071344765A5019067799 @default.
- W2071344765 hasAuthorship W2071344765A5035401835 @default.
- W2071344765 hasAuthorship W2071344765A5045067652 @default.
- W2071344765 hasAuthorship W2071344765A5056346192 @default.
- W2071344765 hasAuthorship W2071344765A5061582640 @default.
- W2071344765 hasAuthorship W2071344765A5064099505 @default.
- W2071344765 hasAuthorship W2071344765A5073031479 @default.
- W2071344765 hasBestOaLocation W20713447651 @default.
- W2071344765 hasConcept C104317684 @default.
- W2071344765 hasConcept C104629339 @default.
- W2071344765 hasConcept C11960822 @default.
- W2071344765 hasConcept C126322002 @default.
- W2071344765 hasConcept C137620995 @default.
- W2071344765 hasConcept C1491633281 @default.
- W2071344765 hasConcept C149402561 @default.
- W2071344765 hasConcept C153911025 @default.
- W2071344765 hasConcept C182996813 @default.
- W2071344765 hasConcept C185592680 @default.
- W2071344765 hasConcept C192118531 @default.
- W2071344765 hasConcept C2779324961 @default.
- W2071344765 hasConcept C30145163 @default.
- W2071344765 hasConcept C54009773 @default.
- W2071344765 hasConcept C541997718 @default.
- W2071344765 hasConcept C54355233 @default.
- W2071344765 hasConcept C55493867 @default.
- W2071344765 hasConcept C62478195 @default.
- W2071344765 hasConcept C71924100 @default.
- W2071344765 hasConcept C81885089 @default.
- W2071344765 hasConcept C85265743 @default.
- W2071344765 hasConcept C86803240 @default.
- W2071344765 hasConcept C95444343 @default.
- W2071344765 hasConceptScore W2071344765C104317684 @default.
- W2071344765 hasConceptScore W2071344765C104629339 @default.
- W2071344765 hasConceptScore W2071344765C11960822 @default.
- W2071344765 hasConceptScore W2071344765C126322002 @default.