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• W2071352479 endingPage "23419" @default.
• W2071352479 startingPage "23419" @default.
• W2071352479 abstract "Candida albicans co-aggregates with Streptococcus gordonii to form biofilms and their interactions in mucosal biofilms may lead to pathogenic synergy. Although the functions of glucosyltransferases (Gtf) of Mutans streptococci have been well characterized, the biological roles of these enzymes in commensal oral streptococci, such as S. gordonii, in oral biofilm communities are less clear.The objective of this work was to explore the role of GtfG, the single Gtf enzyme of S. gordonii, in biofilm interactions with C. albicans.Biofilms were grown under salivary flow in flow cells in vitro, or under static conditions in 96 well plates. A panel of isogenic S. gordonii CH1 gtfG mutants and complemented strains were co-inoculated with C. albicans strain SC5314 to form mixed biofilms. Biofilm accretion and binding interactions between the two organisms were tested. Biofilms were quantified using confocal microscopy or the crystal violet assay.The presence of GtfG enhanced dual biofilm accretion, and sucrose supplementation further augmented dual biofilm formation, pointing to a role of newly synthesized glucans. GtfG also promoted binding to C. albicans preformed biofilms. Soluble α-1,6-glucans played a role in these interactions since: 1) a strain producing only soluble glucans (CH107) formed robust dual biofilms under conditions of salivary flow; and 2) the dual biofilm was susceptible to enzymatic breakdown by dextranase which specifically degrades soluble α-1,6-glucans.Our work identified a novel molecular mechanism for C. albicans and S. gordonii biofilm interactions, mediated by GtfG. This protein promotes early biofilm binding of S. gordonii to C. albicans which leads to increased accretion of streptococcal cells in mixed biofilms. We also showed that soluble glucans, with α-1,6-linkages, promoted inter-generic adhesive interactions." @default.
• W2071352479 created "2016-06-24" @default.
• W2071352479 creator A5017105081 @default.
• W2071352479 creator A5047575569 @default.
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• W2071352479 date "2014-01-01" @default.
• W2071352479 modified "2023-10-01" @default.
• W2071352479 title "<i>Streptococcus gordonii</i> glucosyltransferase promotes biofilm interactions with <i>Candida albicans</i>" @default.
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• W2071352479 doi "https://doi.org/10.3402/jom.v6.23419" @default.
• W2071352479 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3907680" @default.
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