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• W2071357962 abstract "Changes in coagulative and fibrinolytic activities were studied in rats with hyperlipidemia induced by Triton WR-1339 (T-WR). After intravenous injection of T-WR (150, 200 or 300 mg/kg) into S.D. rats, dose-related increases in plasma lipids (total cholesterol, triglyceride, free cholesterol and phospholipid) were observed. In hyperlipidemic rats that received 300 mg/kg of T-WR, decreases in red blood cell count and Hb value were found. Significant increases in the ma value of the thromboelastogram and the fibrinogen level were observed in these T-WR treated rats. The α2-plasmin inhibitor activity was found to decrease dose-relatedly. These results indicate that T-WR induced hyperlipidemia in rats is accompanied with an increase in coagulative activity and an indirect enhancement of fibrinolytic activity." @default.
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• W2071357962 date "1990-01-01" @default.
• W2071357962 modified "2023-09-24" @default.
• W2071357962 title "Changes in coagulative and fibrinolytic activities in Triton WR-1339-induced hyperlipidemia in rats." @default.
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• W2071357962 doi "https://doi.org/10.1254/jjp.52.353" @default.
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