Matches in SemOpenAlex for { <https://semopenalex.org/work/W2071358960> ?p ?o ?g. }
- W2071358960 endingPage "62" @default.
- W2071358960 startingPage "55" @default.
- W2071358960 abstract "We report here the results of clinical, neuroimaging and genetic studies of autosomal dominant dementia and leukoencephalopathy in a Japanese family. Twenty-two individuals in this family were examined clinically (17 living, 5 deceased), neuroradiologically and genetically (16 of 17 living members). Ten (5 deceased) of 22 individuals had early onset dementia (age of onset: 45.2 ± 12.1 years on average) and four of them had multiple white matter lesions and brain atrophy on brain MRI without history of brain ischemic attack. Another four individuals had abnormal white matter lesions on brain MRI without dementia. Linkage studies for chromosome 1q31–42, 14q24.3 and 21q21 responsible for Alzheimer's disease, chromosome 19p13.1–13.2 for cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) and chromosome 3 for familial non-specific dementia suggested no specific haplotypes cosegregated with the disease. Apo E genotypes were E2/2 and E2/3 in this family. Clinical, neuroimaging and genetic studies revealed that the disease in this family was distinguished from known familial dementia. This is the first report of a large Japanese family with autosomal dominant early onset dementia and leukoencephalopathy." @default.
- W2071358960 created "2016-06-24" @default.
- W2071358960 creator A5010682497 @default.
- W2071358960 creator A5046832503 @default.
- W2071358960 creator A5047002755 @default.
- W2071358960 creator A5047410499 @default.
- W2071358960 creator A5051972125 @default.
- W2071358960 creator A5063853635 @default.
- W2071358960 creator A5064695904 @default.
- W2071358960 creator A5068323449 @default.
- W2071358960 creator A5077751499 @default.
- W2071358960 creator A5081199440 @default.
- W2071358960 creator A5081388683 @default.
- W2071358960 creator A5081661146 @default.
- W2071358960 creator A5087609523 @default.
- W2071358960 date "1997-03-01" @default.
- W2071358960 modified "2023-10-16" @default.
- W2071358960 title "Autosomal dominant early onset dementia and leukoencephalopathy in a Japanese family: clinical, neuroimaging and genetic studies" @default.
- W2071358960 cites W120968873 @default.
- W2071358960 cites W1549470101 @default.
- W2071358960 cites W1604929717 @default.
- W2071358960 cites W1647574542 @default.
- W2071358960 cites W1976631434 @default.
- W2071358960 cites W1977309540 @default.
- W2071358960 cites W1981856617 @default.
- W2071358960 cites W2019210560 @default.
- W2071358960 cites W2024691217 @default.
- W2071358960 cites W2031484560 @default.
- W2071358960 cites W2045153164 @default.
- W2071358960 cites W2046209489 @default.
- W2071358960 cites W2046319827 @default.
- W2071358960 cites W2053152816 @default.
- W2071358960 cites W2059252273 @default.
- W2071358960 cites W2060803759 @default.
- W2071358960 cites W2061495518 @default.
- W2071358960 cites W2068653999 @default.
- W2071358960 cites W2075733499 @default.
- W2071358960 cites W2076022853 @default.
- W2071358960 cites W2076152501 @default.
- W2071358960 cites W2082032210 @default.
- W2071358960 cites W2085933472 @default.
- W2071358960 cites W2095251357 @default.
- W2071358960 cites W2108277265 @default.
- W2071358960 cites W2108386133 @default.
- W2071358960 cites W2111333239 @default.
- W2071358960 cites W2141365662 @default.
- W2071358960 cites W2157951377 @default.
- W2071358960 cites W2166474993 @default.
- W2071358960 cites W2400277784 @default.
- W2071358960 cites W2412876803 @default.
- W2071358960 doi "https://doi.org/10.1016/s0022-510x(96)05310-5" @default.
- W2071358960 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9094061" @default.
- W2071358960 hasPublicationYear "1997" @default.
- W2071358960 type Work @default.
- W2071358960 sameAs 2071358960 @default.
- W2071358960 citedByCount "13" @default.
- W2071358960 crossrefType "journal-article" @default.
- W2071358960 hasAuthorship W2071358960A5010682497 @default.
- W2071358960 hasAuthorship W2071358960A5046832503 @default.
- W2071358960 hasAuthorship W2071358960A5047002755 @default.
- W2071358960 hasAuthorship W2071358960A5047410499 @default.
- W2071358960 hasAuthorship W2071358960A5051972125 @default.
- W2071358960 hasAuthorship W2071358960A5063853635 @default.
- W2071358960 hasAuthorship W2071358960A5064695904 @default.
- W2071358960 hasAuthorship W2071358960A5068323449 @default.
- W2071358960 hasAuthorship W2071358960A5077751499 @default.
- W2071358960 hasAuthorship W2071358960A5081199440 @default.
- W2071358960 hasAuthorship W2071358960A5081388683 @default.
- W2071358960 hasAuthorship W2071358960A5081661146 @default.
- W2071358960 hasAuthorship W2071358960A5087609523 @default.
- W2071358960 hasConcept C118552586 @default.
- W2071358960 hasConcept C126322002 @default.
- W2071358960 hasConcept C126838900 @default.
- W2071358960 hasConcept C142724271 @default.
- W2071358960 hasConcept C143409427 @default.
- W2071358960 hasConcept C2778583010 @default.
- W2071358960 hasConcept C2779134260 @default.
- W2071358960 hasConcept C2779268494 @default.
- W2071358960 hasConcept C2779483572 @default.
- W2071358960 hasConcept C2780130745 @default.
- W2071358960 hasConcept C2781172350 @default.
- W2071358960 hasConcept C2781179581 @default.
- W2071358960 hasConcept C2781192897 @default.
- W2071358960 hasConcept C54355233 @default.
- W2071358960 hasConcept C58693492 @default.
- W2071358960 hasConcept C71924100 @default.
- W2071358960 hasConcept C86803240 @default.
- W2071358960 hasConceptScore W2071358960C118552586 @default.
- W2071358960 hasConceptScore W2071358960C126322002 @default.
- W2071358960 hasConceptScore W2071358960C126838900 @default.
- W2071358960 hasConceptScore W2071358960C142724271 @default.
- W2071358960 hasConceptScore W2071358960C143409427 @default.
- W2071358960 hasConceptScore W2071358960C2778583010 @default.
- W2071358960 hasConceptScore W2071358960C2779134260 @default.
- W2071358960 hasConceptScore W2071358960C2779268494 @default.
- W2071358960 hasConceptScore W2071358960C2779483572 @default.
- W2071358960 hasConceptScore W2071358960C2780130745 @default.
- W2071358960 hasConceptScore W2071358960C2781172350 @default.