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- W2071361136 endingPage "541" @default.
- W2071361136 startingPage "531" @default.
- W2071361136 abstract "The interplay between p53 and apoptosis in diseases such as cancer, neurodegeneration, ischemia and atherosclerosis underscores the need to understand the complexity of p53 networks. Here, we highlight recent studies of p53-induced apoptosis in human diseases, with a focus on the modulation of liver cell apoptosis. In addition, recent work has provided new insights into mechanisms underlying the antiapoptotic functions of the endogenous bile acid ursodeoxycholic acid (UDCA), suggesting that the finely tuned, complex control of p53 by Mdm2 is a key step in the UDCA modulation of deregulated, p53-triggered apoptosis. The effect of targeting cell death signaling proteins has been established in preclinical models of human diseases. Finally, we review recent therapeutic strategies and clinical applications of targeted agents, with a particular emphasis on the potential use of UDCA." @default.
- W2071361136 created "2016-06-24" @default.
- W2071361136 creator A5004169355 @default.
- W2071361136 creator A5069186777 @default.
- W2071361136 creator A5074043200 @default.
- W2071361136 creator A5082941446 @default.
- W2071361136 date "2009-11-01" @default.
- W2071361136 modified "2023-09-26" @default.
- W2071361136 title "p53 and the regulation of hepatocyte apoptosis: implications for disease pathogenesis" @default.
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