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- W2071365780 abstract "Genome-wide DNA methylation reprogramming occurs in mouse primordial germ cells (PGCs) and preimplantation embryos, but the precise dynamics and biological outcomes are largely unknown. We have carried out whole-genome bisulfite sequencing (BS-Seq) and RNA-Seq across key stages from E6.5 epiblast to E16.5 PGCs. Global loss of methylation takes place during PGC expansion and migration with evidence for passive demethylation, but sequences that carry long-term epigenetic memory (imprints, CpG islands on the X chromosome, germline-specific genes) only become demethylated upon entry of PGCs into the gonads. The transcriptional profile of PGCs is tightly controlled despite global hypomethylation, with transient expression of the pluripotency network, suggesting that reprogramming and pluripotency are inextricably linked. Our results provide a framework for the understanding of the epigenetic ground state of pluripotency in the germline." @default.
- W2071365780 created "2016-06-24" @default.
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- W2071365780 date "2012-12-01" @default.
- W2071365780 modified "2023-10-17" @default.
- W2071365780 title "The Dynamics of Genome-wide DNA Methylation Reprogramming in Mouse Primordial Germ Cells" @default.
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- W2071365780 cites W1964485083 @default.
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- W2071365780 cites W1970488458 @default.
- W2071365780 cites W1975231696 @default.
- W2071365780 cites W1986849101 @default.
- W2071365780 cites W1997796525 @default.
- W2071365780 cites W1998841413 @default.
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- W2071365780 cites W2004457665 @default.
- W2071365780 cites W2006557744 @default.
- W2071365780 cites W2014623973 @default.
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- W2071365780 cites W2026529460 @default.
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- W2071365780 doi "https://doi.org/10.1016/j.molcel.2012.11.001" @default.
- W2071365780 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3533687" @default.
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