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Matches in SemOpenAlex for { <https://semopenalex.org/work/W2071369888> ?p ?o ?g. }

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• W2071369888 abstract "A flexible, trifunctional poly(ethylene glycol)-succinamide-Lysine-Lysine-maleimide (PEG-SU-Lys-Lys-mal) linker was employed to simultaneously allow biotin tagging and cell-surface targeting through an integrin alpha(4)beta(1)-binding peptidomimetic that was regiospecifically conjugated to an IgG1-derived Fc fragment with an engineered C-terminal selenocysteine residue. The resulting antibody derivative mediates Fc receptor binding by virtue of the Fc protein and selectively targets cancer cells expressing human integrin alpha(4)beta(1). The PEG-SU-Lys-Lys-mal linker may have general utility as an organic tether for the construction of antibody-drug conjugates." @default.
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• W2071369888 date "2008-11-01" @default.
• W2071369888 modified "2023-09-24" @default.
• W2071369888 title "Application of a trifunctional reactive linker for the construction of antibody–drug hybrid conjugates" @default.
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• W2071369888 doi "https://doi.org/10.1016/j.bmcl.2008.09.078" @default.
• W2071369888 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3461582" @default.
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