FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2071380917> ?p ?o ?g. }

• W2071380917 endingPage "67" @default.
• W2071380917 startingPage "59" @default.
• W2071380917 abstract "Lysophosphatidic acid (LPA) is a class of bioactive lyso-phospholipid that mediates most of its biological effects through a family of G protein-coupled receptors of which six have been identified. The role of the LPA pathway in driving chronic lung diseases such as idiopathic pulmonary fibrosis (IPF) has gained considerable academic and industry attention. Modulation of the pulmonary artery endothelial barrier function by the LPA1 receptor has been shown to drive pulmonary fibrosis in murine models of disease. The purpose of this study was (i) to assess the effect of LPA on the barrier function of human pulmonary arterial (HPAEC) and microvascular (HMVEC) endothelial cells and (ii) to identify the LPA receptor subtype(s) responsible for changes in human pulmonary endothelial cell permeability using LPA receptor antagonists and siRNA technology. Analysis of the LPA receptor subtype expression demonstrated predominant expression of LPA2 and LPA6 receptor subtypes in both HPAECs and HMVECs. HPAECs also exhibit low expression of LPA1, LPA3, and LPA4 receptor subtypes. Treatment of cells with increasing concentrations of LPA caused loss of barrier function in HPAECs but not HMVECs, despite both cell types exhibiting very similar LPA receptor expression profiles. The LPA-mediated loss of barrier function in HPAECs appears to be independent of the LPA1 receptor and likely to be mediated via the LPA6 receptor although we cannot exclude an additional role for the LPA2 and LPA4 receptors in mediating these effects. These results suggest cell-specific mechanisms exist in human pulmonary endothelial cells to permit regulation of barrier function downstream of LPA receptors. More importantly, our data indicate that selective LPA1 receptor antagonism may be insufficient for therapeutic use in pulmonary diseases where impaired endothelial barrier function is related to disease initiation and progression." @default.
• W2071380917 created "2016-06-24" @default.
• W2071380917 creator A5014033382 @default.
• W2071380917 creator A5015228968 @default.
• W2071380917 creator A5019097174 @default.
• W2071380917 creator A5021167157 @default.
• W2071380917 creator A5028210459 @default.
• W2071380917 creator A5034761124 @default.
• W2071380917 creator A5036340684 @default.
• W2071380917 creator A5039371093 @default.
• W2071380917 creator A5048420468 @default.
• W2071380917 creator A5061402622 @default.
• W2071380917 creator A5065225093 @default.
• W2071380917 creator A5066095219 @default.
• W2071380917 creator A5076275792 @default.
• W2071380917 creator A5087892949 @default.
• W2071380917 creator A5090212073 @default.
• W2071380917 date "2013-01-01" @default.
• W2071380917 modified "2023-09-28" @default.
• W2071380917 title "Comparing the differential effects of LPA on the barrier function of human pulmonary endothelial cells" @default.
• W2071380917 cites W1522803047 @default.
• W2071380917 cites W1551940170 @default.
• W2071380917 cites W1566845866 @default.
• W2071380917 cites W1582393841 @default.
• W2071380917 cites W1854779166 @default.
• W2071380917 cites W1963652501 @default.
• W2071380917 cites W1967780469 @default.
• W2071380917 cites W1969715124 @default.
• W2071380917 cites W1974968209 @default.
• W2071380917 cites W1975929220 @default.
• W2071380917 cites W1980611128 @default.
• W2071380917 cites W1985899534 @default.
• W2071380917 cites W2005959847 @default.
• W2071380917 cites W2012687414 @default.
• W2071380917 cites W2019121101 @default.
• W2071380917 cites W2019649305 @default.
• W2071380917 cites W2046658218 @default.
• W2071380917 cites W2049404716 @default.
• W2071380917 cites W2057051750 @default.
• W2071380917 cites W2060715963 @default.
• W2071380917 cites W2063739835 @default.
• W2071380917 cites W2065492096 @default.
• W2071380917 cites W2071159103 @default.
• W2071380917 cites W2079200448 @default.
• W2071380917 cites W2079878922 @default.
• W2071380917 cites W2080679386 @default.
• W2071380917 cites W2087823408 @default.
• W2071380917 cites W2090744060 @default.
• W2071380917 cites W2096546399 @default.
• W2071380917 cites W2106514058 @default.
• W2071380917 cites W2112451265 @default.
• W2071380917 cites W2117781884 @default.
• W2071380917 cites W2131032222 @default.
• W2071380917 cites W2141424955 @default.
• W2071380917 cites W2169198071 @default.
• W2071380917 cites W2410915766 @default.
• W2071380917 cites W59129145 @default.
• W2071380917 doi "https://doi.org/10.1016/j.mvr.2012.10.004" @default.
• W2071380917 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23084965" @default.
• W2071380917 hasPublicationYear "2013" @default.
• W2071380917 type Work @default.
• W2071380917 sameAs 2071380917 @default.
• W2071380917 citedByCount "28" @default.
• W2071380917 countsByYear W20713809172013 @default.
• W2071380917 countsByYear W20713809172014 @default.
• W2071380917 countsByYear W20713809172015 @default.
• W2071380917 countsByYear W20713809172016 @default.
• W2071380917 countsByYear W20713809172017 @default.
• W2071380917 countsByYear W20713809172018 @default.
• W2071380917 countsByYear W20713809172019 @default.
• W2071380917 countsByYear W20713809172020 @default.
• W2071380917 countsByYear W20713809172021 @default.
• W2071380917 countsByYear W20713809172022 @default.
• W2071380917 crossrefType "journal-article" @default.
• W2071380917 hasAuthorship W2071380917A5014033382 @default.
• W2071380917 hasAuthorship W2071380917A5015228968 @default.
• W2071380917 hasAuthorship W2071380917A5019097174 @default.
• W2071380917 hasAuthorship W2071380917A5021167157 @default.
• W2071380917 hasAuthorship W2071380917A5028210459 @default.
• W2071380917 hasAuthorship W2071380917A5034761124 @default.
• W2071380917 hasAuthorship W2071380917A5036340684 @default.
• W2071380917 hasAuthorship W2071380917A5039371093 @default.
• W2071380917 hasAuthorship W2071380917A5048420468 @default.
• W2071380917 hasAuthorship W2071380917A5061402622 @default.
• W2071380917 hasAuthorship W2071380917A5065225093 @default.
• W2071380917 hasAuthorship W2071380917A5066095219 @default.
• W2071380917 hasAuthorship W2071380917A5076275792 @default.
• W2071380917 hasAuthorship W2071380917A5087892949 @default.
• W2071380917 hasAuthorship W2071380917A5090212073 @default.
• W2071380917 hasConcept C123012128 @default.
• W2071380917 hasConcept C170493617 @default.
• W2071380917 hasConcept C202751555 @default.
• W2071380917 hasConcept C203014093 @default.
• W2071380917 hasConcept C2776661833 @default.
• W2071380917 hasConcept C2993002077 @default.
• W2071380917 hasConcept C502942594 @default.
• W2071380917 hasConcept C51911345 @default.
• W2071380917 hasConcept C55493867 @default.

• next