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- W2071381633 abstract "In this study, we focused on alginate as a physical tissue adhesion barrier material. The alginate has a muco-adhesive property in the solid state and becomes a viscous slippery gel-like solution in the dissolved state. We hypothesized that the alginate film without cross-linking can be a good candidate as a tissue adhesion barrier. The un-cross-linked alginate film may stably adhere onto a wound owing to its muco-adhesive property and, thus, does not need suturing to fix it, and then the film may slowly change into a slippery gel by hydration when in contact with body fluid and, thus, effectively separate the wound from the surrounding tissue without adhesion. To verify our hypothesis, we fabricated a un-cross-linked alginate film and its potential as a tissue adhesion barrier was evaluated through the comparison with various types of alginate (viscous solution and gel as well as cross-linked film) and a commercialized tissue adhesion barrier, Interceed™, by the investigation of post-surgical peritoneal adhesion using a rat model. From the animal study, it was observed that the un-cross-linked alginate film was more effective for the prevention of peritoneal tissue adhesion than other types of alginates, including the commercialized one, probably owing to its unique muco-adhesive property (providing residence stability without suturing at the injured site) and lubricant property (by hydration in contact with body fluid) during wound healing. The un-cross-linked alginate film also showed a low inflammatory response and did not lead to specific histological influence during the wound healing. From these observations, the un-cross-linked alginate film is expected to be a simple and efficient tissue adhesion barrier applicable to various injury tissues." @default.
- W2071381633 created "2016-06-24" @default.
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- W2071381633 date "2010-01-01" @default.
- W2071381633 modified "2023-09-24" @default.
- W2071381633 title "Alginate Film as a Novel Post-Surgical Tissue Adhesion Barrier" @default.
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- W2071381633 doi "https://doi.org/10.1163/156856209x435835" @default.
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