FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2071382016> ?p ?o ?g. }

• W2071382016 endingPage "919" @default.
• W2071382016 startingPage "909" @default.
• W2071382016 abstract "Transforming growth factor (TGF)-beta regulates the expression of matrix metalloproteinases (MMPs) and components of the extracellular matrix, thereby profoundly affecting the microenvironment of cells including cancerous ones. We studied MMP-10 induction by TGF-beta in mammary epithelial cells and found that the induction was dependent on the myocyte enhancer factor (MEF)-2 transcription factor. TGF-beta upregulated the gene promoter through the MEF2 site, and knockdown of the MEF2A transcription factor negatively affected MMP-10 induction, whereas its overexpression had a positive effect on the induction. In response to TGF-beta, acetylation and concomitant binding of MEF2A to the promoter region increased, thus suggesting a critical role of MEF2A in transactivation of MMP-10 by TGF-beta. Consistent with the fact that class IIa histone deacetylases (HDACs) interact with MEF2 and suppress transcription, knockdown of HDACs increased and their overexpression inhibited MMP-10 expression. Intriguingly, TGF-beta promoted proteasome-dependent degradation of HDACs. Consistent with this, acetylation of core histones was increased around the MEF2 site of the MMP-10 promoter by TGF-beta and alleviated by overexpression of HDACs. Collectively, it is possible that TGF-beta transcriptionally upregulated MMP-10 through activation of MEF2A, concomitant with acetylation of core histones increasing around the promoter, as a consequence of degradation of the class IIa HDACs." @default.
• W2071382016 created "2016-06-24" @default.
• W2071382016 creator A5020305971 @default.
• W2071382016 creator A5026284263 @default.
• W2071382016 creator A5050749154 @default.
• W2071382016 creator A5076082941 @default.
• W2071382016 date "2009-11-23" @default.
• W2071382016 modified "2023-10-16" @default.
• W2071382016 title "Transcriptional induction of MMP-10 by TGF-β, mediated by activation of MEF2A and downregulation of class IIa HDACs" @default.
• W2071382016 cites W1488829562 @default.
• W2071382016 cites W1565561072 @default.
• W2071382016 cites W1606525046 @default.
• W2071382016 cites W1766090917 @default.
• W2071382016 cites W1967476432 @default.
• W2071382016 cites W1975600980 @default.
• W2071382016 cites W1977657840 @default.
• W2071382016 cites W1984162437 @default.
• W2071382016 cites W1990692433 @default.
• W2071382016 cites W1997431505 @default.
• W2071382016 cites W2005376824 @default.
• W2071382016 cites W2008340135 @default.
• W2071382016 cites W2010224007 @default.
• W2071382016 cites W2010466297 @default.
• W2071382016 cites W2011182719 @default.
• W2071382016 cites W2013053579 @default.
• W2071382016 cites W2016703397 @default.
• W2071382016 cites W2032328453 @default.
• W2071382016 cites W2037786647 @default.
• W2071382016 cites W2041769826 @default.
• W2071382016 cites W2044702738 @default.
• W2071382016 cites W2046690108 @default.
• W2071382016 cites W2049961455 @default.
• W2071382016 cites W2056941563 @default.
• W2071382016 cites W2058733924 @default.
• W2071382016 cites W2069951758 @default.
• W2071382016 cites W2071515790 @default.
• W2071382016 cites W2073229191 @default.
• W2071382016 cites W2074629755 @default.
• W2071382016 cites W2080239627 @default.
• W2071382016 cites W2086768605 @default.
• W2071382016 cites W2092344861 @default.
• W2071382016 cites W2111154069 @default.
• W2071382016 cites W2113457132 @default.
• W2071382016 cites W2119522973 @default.
• W2071382016 cites W2127690474 @default.
• W2071382016 cites W2129567613 @default.
• W2071382016 cites W2131936396 @default.
• W2071382016 cites W2139503369 @default.
• W2071382016 cites W2148583445 @default.
• W2071382016 cites W2169187666 @default.
• W2071382016 cites W2171308503 @default.
• W2071382016 cites W4237747603 @default.
• W2071382016 doi "https://doi.org/10.1038/onc.2009.387" @default.
• W2071382016 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19935709" @default.
• W2071382016 hasPublicationYear "2009" @default.
• W2071382016 type Work @default.
• W2071382016 sameAs 2071382016 @default.
• W2071382016 citedByCount "38" @default.
• W2071382016 countsByYear W20713820162012 @default.
• W2071382016 countsByYear W20713820162013 @default.
• W2071382016 countsByYear W20713820162014 @default.
• W2071382016 countsByYear W20713820162015 @default.
• W2071382016 countsByYear W20713820162016 @default.
• W2071382016 countsByYear W20713820162017 @default.
• W2071382016 countsByYear W20713820162018 @default.
• W2071382016 countsByYear W20713820162019 @default.
• W2071382016 countsByYear W20713820162020 @default.
• W2071382016 countsByYear W20713820162021 @default.
• W2071382016 countsByYear W20713820162022 @default.
• W2071382016 crossrefType "journal-article" @default.
• W2071382016 hasAuthorship W2071382016A5020305971 @default.
• W2071382016 hasAuthorship W2071382016A5026284263 @default.
• W2071382016 hasAuthorship W2071382016A5050749154 @default.
• W2071382016 hasAuthorship W2071382016A5076082941 @default.
• W2071382016 hasBestOaLocation W20713820161 @default.
• W2071382016 hasConcept C104317684 @default.
• W2071382016 hasConcept C111936080 @default.
• W2071382016 hasConcept C118131993 @default.
• W2071382016 hasConcept C119157956 @default.
• W2071382016 hasConcept C127561419 @default.
• W2071382016 hasConcept C1292079 @default.
• W2071382016 hasConcept C153911025 @default.
• W2071382016 hasConcept C173396325 @default.
• W2071382016 hasConcept C2778229498 @default.
• W2071382016 hasConcept C502942594 @default.
• W2071382016 hasConcept C51183755 @default.
• W2071382016 hasConcept C54355233 @default.
• W2071382016 hasConcept C55493867 @default.
• W2071382016 hasConcept C64927066 @default.
• W2071382016 hasConcept C81885089 @default.
• W2071382016 hasConcept C86339819 @default.
• W2071382016 hasConcept C86803240 @default.
• W2071382016 hasConcept C95444343 @default.
• W2071382016 hasConceptScore W2071382016C104317684 @default.
• W2071382016 hasConceptScore W2071382016C111936080 @default.
• W2071382016 hasConceptScore W2071382016C118131993 @default.
• W2071382016 hasConceptScore W2071382016C119157956 @default.
• W2071382016 hasConceptScore W2071382016C127561419 @default.

• next