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• W2071382289 abstract "Relatively little work has been done on the influence of the position of the cell in the cell cycle on ionizing radiation-induced mutagenesis. We synchronized WTK1 human lymphoblastoid cells with 200 microM lovastatin for 48 h; under these conditions more than 80% of the cells were arrested in G1 phase. Upon release, there was a 12-15-h lag followed by movement of a large fraction into S phase. We irradiated cells with either 1.5 Gy X rays at 1, 15, 18, 21 or 24 h or 1.5 Gy gamma rays at 1, 5, 10, 15 or 24 h after release from lovastatin. We showed that WTK1 cells were most sensitive to ionizing radiation-induced toxicity in G1 and into S phase, and more resistant in mid to late S and G2/M phase. Somewhat surprisingly, we found that the two different gene loci had different sensitivities to radiation-induced mutation through the cell cycle. Cells in late G1 through mid-S phase were most sensitive to radiation-induced mutations at the autosomal thymidine kinase (TK) locus, whereas G1 phase was the most sensitive phase at the X-linked hypoxanthine guanine phosphoribosyl transferase (HPRT) locus." @default.
• W2071382289 created "2016-06-24" @default.
• W2071382289 creator A5061261371 @default.
• W2071382289 creator A5071094498 @default.
• W2071382289 date "1996-11-01" @default.
• W2071382289 modified "2023-09-23" @default.
• W2071382289 title "Effects of Cell Cycle Position on Ionizing Radiation Mutagenesis. I. Quantitative Assays of Two Genetic Loci in a Human Lymphoblastoid Cell Line" @default.
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• W2071382289 doi "https://doi.org/10.2307/3579549" @default.
• W2071382289 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8896575" @default.
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