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• W2071386184 abstract "<b><i>Background:</i></b> Recent studies have shown that hyperuricemia is an independent risk factor for cardiovascular disease. However, few studies have examined whether hyperuricemia is a risk factor for chronic kidney disease (CKD), so to investigate the significance of hyperuricemia as a risk factor for CKD, we analyzed data collected in annual health check-ups. <b><i>Methods:</i></b> The data of 11,048 subjects who underwent an annual health check-up were analyzed in cross-sectional and longitudinal studies. <b><i>Results:</i></b> After adjustment for covariate factors, a multivariate logistic regression analysis showed that age, systolic blood pressure, diastolic blood pressure, LDL-cholesterol, triglyceride, HbA1c, and uric acid (hazard ratio: 1.66) were independently and significantly associated with CKD. We also analyzed the data of 1,652 subjects who underwent annual health check-ups for 5 consecutive years. Over that 5-year period, 93 subjects developed CKD. We compared the baseline data of the subjects who developed CKD with the data of those who did not, and we found significant between-group differences in gender, age, HDL-cholesterol, the estimated glomerular filtration rate, and uric acid. After adjustment for several covariate factors, a multivariate Cox regression analysis showed that only age and hyperuricemia (hazard ratio: 1.36) were independent risk factors for the development of CKD. <b><i>Conclusions:</i></b> We found that hyperuricemia is an independent risk factor for the development of CKD." @default.
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• W2071386184 date "2014-01-15" @default.
• W2071386184 modified "2023-09-26" @default.
• W2071386184 title "Hyperuricemia Is a Significant Risk Factor for the Onset of Chronic Kidney Disease" @default.
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• W2071386184 doi "https://doi.org/10.1159/000355639" @default.
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