FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2071392945> ?p ?o ?g. }

• W2071392945 endingPage "99" @default.
• W2071392945 startingPage "89" @default.
• W2071392945 abstract "Vasodilators play an important role in the treatment of the patient with severe heart failure and increased systemic vascular resistance. However, there are both clinical data and theoretic reasons to anticipate that some degree of tolerance may develop during the long-term use of most agents. The cause of the increased vascular resistance of heart failure is not completely understood, but it appears to be related to a number of neuroendocrine, molecular and physical mechanisms including increased activity of the sympathetic nervous and renin-angiotensin systems, and increased vascular stiffness due to intra- and extracellular sodium and fluid accumulation. Not surprisingly, a lowering of systemic vascular resistance either by direct smooth muscle relaxers or by blockade of specific neuroendocrine systems may result in a number of compensatory responses at the neuroendocrine and/or molecular level. The over-all effectiveness of a particular vasodilator is the net sum of its direct pharmacologic action, and the neuroendocrine and molecular responses to the drug. The specific compensatory mechanisms activated depend on several factors including the type of vasodilator used, the dose employed, the baseline neuroendocrine status of the patient, the severity of heart failure and the functional integrity of various reflex systems. Although not directly applicable to patients with heart failure, much information derived from the use of these agents to treat patients with hypertension and angina pectoris suggests several potential mechanisms by which tolerance may develop to virtually all classes of vasodilators. The major types of vasodilators are discussed with regard to their potential mechanisms of tolerance. Finally, the evidence currently available from long-term studies is reviewed in order to assess the potential relevance of vasodilator tolerance to the clinical management of the patient with heart failure." @default.
• W2071392945 created "2016-06-24" @default.
• W2071392945 creator A5031837459 @default.
• W2071392945 creator A5041151041 @default.
• W2071392945 creator A5042926181 @default.
• W2071392945 creator A5047140893 @default.
• W2071392945 date "1981-07-01" @default.
• W2071392945 modified "2023-09-27" @default.
• W2071392945 title "Mechanisms and implications of vasodilator tolerance in the treatment of congestive heart failure" @default.
• W2071392945 cites W1521528949 @default.
• W2071392945 cites W1593722016 @default.
• W2071392945 cites W1911188572 @default.
• W2071392945 cites W1968786943 @default.
• W2071392945 cites W1974988319 @default.
• W2071392945 cites W1975180379 @default.
• W2071392945 cites W1981106892 @default.
• W2071392945 cites W1983902487 @default.
• W2071392945 cites W1987426214 @default.
• W2071392945 cites W1990656876 @default.
• W2071392945 cites W1993819372 @default.
• W2071392945 cites W1995904912 @default.
• W2071392945 cites W1996316222 @default.
• W2071392945 cites W1997237739 @default.
• W2071392945 cites W1999022133 @default.
• W2071392945 cites W2001725885 @default.
• W2071392945 cites W2002848896 @default.
• W2071392945 cites W2007422130 @default.
• W2071392945 cites W2011026340 @default.
• W2071392945 cites W2013024376 @default.
• W2071392945 cites W2013865516 @default.
• W2071392945 cites W2015214964 @default.
• W2071392945 cites W2018258360 @default.
• W2071392945 cites W2020380044 @default.
• W2071392945 cites W2023338645 @default.
• W2071392945 cites W2026867709 @default.
• W2071392945 cites W2027073004 @default.
• W2071392945 cites W2027268907 @default.
• W2071392945 cites W2029379316 @default.
• W2071392945 cites W2029811800 @default.
• W2071392945 cites W2031180767 @default.
• W2071392945 cites W2032846053 @default.
• W2071392945 cites W2035976456 @default.
• W2071392945 cites W2037895230 @default.
• W2071392945 cites W2039120849 @default.
• W2071392945 cites W2041700875 @default.
• W2071392945 cites W2043390031 @default.
• W2071392945 cites W2045280290 @default.
• W2071392945 cites W2046891147 @default.
• W2071392945 cites W2047882602 @default.
• W2071392945 cites W2052325698 @default.
• W2071392945 cites W2054635454 @default.
• W2071392945 cites W2058909622 @default.
• W2071392945 cites W2060988580 @default.
• W2071392945 cites W2061559645 @default.
• W2071392945 cites W2068114415 @default.
• W2071392945 cites W2075238739 @default.
• W2071392945 cites W2077552324 @default.
• W2071392945 cites W2079256064 @default.
• W2071392945 cites W2081409739 @default.
• W2071392945 cites W2081685729 @default.
• W2071392945 cites W2082798457 @default.
• W2071392945 cites W2083609758 @default.
• W2071392945 cites W2084283682 @default.
• W2071392945 cites W2085481555 @default.
• W2071392945 cites W2087209163 @default.
• W2071392945 cites W2093005724 @default.
• W2071392945 cites W2095038529 @default.
• W2071392945 cites W2099920556 @default.
• W2071392945 cites W2103575900 @default.
• W2071392945 cites W2111243875 @default.
• W2071392945 cites W2120530735 @default.
• W2071392945 cites W2147277326 @default.
• W2071392945 cites W2149994558 @default.
• W2071392945 cites W2156403936 @default.
• W2071392945 cites W2162268316 @default.
• W2071392945 cites W2171630567 @default.
• W2071392945 cites W2325797916 @default.
• W2071392945 cites W2339067407 @default.
• W2071392945 cites W2339315384 @default.
• W2071392945 cites W2339719629 @default.
• W2071392945 cites W2340670561 @default.
• W2071392945 cites W2394579992 @default.
• W2071392945 cites W2408071900 @default.
• W2071392945 cites W2883805808 @default.
• W2071392945 doi "https://doi.org/10.1016/0002-9343(81)90263-1" @default.
• W2071392945 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6166194" @default.
• W2071392945 hasPublicationYear "1981" @default.
• W2071392945 type Work @default.
• W2071392945 sameAs 2071392945 @default.
• W2071392945 citedByCount "89" @default.
• W2071392945 countsByYear W20713929452022 @default.
• W2071392945 crossrefType "journal-article" @default.
• W2071392945 hasAuthorship W2071392945A5031837459 @default.
• W2071392945 hasAuthorship W2071392945A5041151041 @default.
• W2071392945 hasAuthorship W2071392945A5042926181 @default.
• W2071392945 hasAuthorship W2071392945A5047140893 @default.
• W2071392945 hasConcept C120770815 @default.
• W2071392945 hasConcept C126322002 @default.

• next